Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (9): 1410.

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Improvement Preparation Method of N3-(Hydroxyalkyl) Tagefur and Synthesis and Activity of Its Cyclic Glycerophospholipid Conjugate

XU Xin-Hua, CHEN Huan-Ming, CHEN Ru-Yu   

  1. Institute of Elemento-Organic Chemistry, The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:1999-11-08 Online:2000-09-24 Published:2000-09-24

Abstract: N1-(2-Fursnidyl)-5-fluorouracil reacted with multimethylenes chlorohydrin in the presence of NaHCO3 in acetonitrile at 80 ℃ to give N1-(2-furanidyl)-N3-(hydroxyalkyl)-5-fulorouracils in a high yield (≥93%). Their cyclic glycerophospholipid conjugates were synthesized and had a good activity against the man urinary bladder cancer cell in vitro.

Key words: Cyclic glycerophospholipid, Conjugates, Antitumor activity, Tagefur

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