Investigation of the Association Between Bovine Serum Albumin(BSA) and Aluminum Tetrasulfonated Phthalocyanine(AlS4Pc) by Fluorescence Anisotropy

Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (8): 1218.

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Investigation of the Association Between Bovine Serum Albumin(BSA) and Aluminum Tetrasulfonated Phthalocyanine(AlS₄Pc) by Fluorescence Anisotropy

LI Dong-Hui¹, PENG Xing-Yue², YE Dong³, XU Jin-Gou³

1. Cancer Research Center, Xiamen University, Xiamen 361005;
2. Department of Biology, Xiamen University, Xiamen 361005;
3. Department of Chemistry and the Key Laboratory of Analytical Sciences of MOE, Xiamen University, Xiamen 361005

Received:1998-09-04 Online:1999-08-24 Published:1999-08-24

Abstract

Abstract: Fluorescence anisotropy was employed for the investigation of the association between AlS₄Pc and BSA. The average binding number of AlS₄Pc to BSAwas calculated and the constants of association reaction occurring in the medium of pH7.0 were shown. The results revealed that the interaction between AlS₄Pc and BSAwas strong, which implied that AlS₄Pc may be stored and transferred by serum albumin. The merits of the method used were also pointed out.

Key words: Phthalocyanine, Fluorescence polarization, Fluorescence anisotropy, Albumin

CLC Number:

O657.32

TrendMD:

LI Dong-Hui, PENG Xing-Yue, YE Dong, XU Jin-Gou . Investigation of the Association Between Bovine Serum Albumin(BSA) and Aluminum Tetrasulfonated Phthalocyanine(AlS₄Pc) by Fluorescence Anisotropy[J]. Chem. J. Chinese Universities, 1999, 20(8): 1218.

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Investigation of the Association Between Bovine Serum Albumin(BSA) and Aluminum Tetrasulfonated Phthalocyanine(AlS₄Pc) by Fluorescence Anisotropy

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