The Modification of Taxol with Improving Water Solubility

Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (7): 1073.

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The Modification of Taxol with Improving Water Solubility

QIU Xiao-Hang, CHAO Hui, ZHOU Yong-Qia

Department of Chemistry, Nankai University, Tianjin, 300071

Received:1998-12-23 Online:1999-07-24 Published:1999-07-24

Abstract

Abstract: TaxoLIs a product isolated from the pacitic yew tree and is a potent microtubule-stablizing agent which has been approved for treatment of otherwise intractable ovarian can-cer and beast cancer. Despite taxol’s therapeutic promise, its aqueous insolubility hampers its clinical application. Here we report two ways to modify taxol with BSA or HSA which can improve taxol's solubility. The IRdata and UVabsorption are given to confirm the modification.

Key words: Taxol, BSA, HSA, Modification

CLC Number:

O614.24

TrendMD:

QIU Xiao-Hang, CHAO Hui, ZHOU Yong-Qia . The Modification of Taxol with Improving Water Solubility[J]. Chem. J. Chinese Universities, 1999, 20(7): 1073.

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