Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (9): 1476.

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Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives

LUO Yi¹, ZHUO Ren-Xi², FAN Chang-Lie²

1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871;
2. Department of Chemistry, Wuhan University, Wuhan, 430072

Received:1994-09-20 Revised:1995-01-04 Online:1995-09-24 Published:1995-09-24

Abstract

Abstract: The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems. Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting, Gd-DTPA is the first MRI contrast agent clinically used, the chelates of Gd(Ⅲ) and DTPA derivatives were more selective and less toxic than Gd-DTPA. In this paper,a series of amino acids and oligopeptides of Gd-DTPAderivatives were synthesized, The structures of these chelates were confirmed by IR and elementary analysis. Toxicity of chelate was almost the same as Gd-DTPA.The spin-lattice relaxivity (R₁) of these chelates was a little bit larger than that of Gd-DTPA.

Key words: Gd(Ⅲ)-DTPA, Amino acid, Oligopeptide, Toxicity, Spin-lattice relaxivity

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LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie. Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives[J]. Chem. J. Chinese Universities, 1995, 16(9): 1476.

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Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives

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