Syntheses and Properties of Di-tertiary Alkylphosphinic Acids

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (6): 849.

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Syntheses and Properties of Di-tertiary Alkylphosphinic Acids

HU Wen-Xiang

Institute of Pharmacology and Toxicology, Chinese Academy of Military Medical Sciences, Beijing, 100850

Received:1993-11-05 Revised:1994-03-18 Online:1994-06-24 Published:1994-06-24

Abstract

Abstract: Di-t-butyl, di-t-pentyl, di-t-octyl phosphinic acids were synthesized by the reaction of Grignard reagents with phosphorus trichloride, followed by oxidation with 30 percent hydrogen peroxide.The preparation of Grignard reagent from tertalkylchlorides is easier than that from tertalkylbromides, The structural identification and stereochemical analysis were also studied by pK_a values, MSand 1H, ¹³C, ³¹P NMR.

Key words: Di-tertiary alkyl phosphinic acid, High hindering, Grignard reagent, PK_a, NMR

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HU Wen-Xiang. Syntheses and Properties of Di-tertiary Alkylphosphinic Acids[J]. Chem. J. Chinese Universities, 1994, 15(6): 849.

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