Determination of Very Long Chain Fatty Acids in Plasma by Capillary Gas Chromatography

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (3): 364.

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Determination of Very Long Chain Fatty Acids in Plasma by Capillary Gas Chromatography

ZHANG Shu-Feng¹, CHANG Li-Wen²

1. Department of Chemistry, Ningxia University, Yinchuan, 750021;
2. Institute of Chemistry, Academia Sinica, 100080

Received:1993-03-15 Revised:1993-07-20 Online:1994-03-24 Published:1994-03-24

Abstract

Abstract: Capillary gas chromatographic method was employed for determining very long chain fatty acids in the plasma of patients with Adrenoleucodystrophy(ALD)and healthy controls.Very long chain fatty acids in the plasma were extracted and methylated with CH₃OH-C₆H₆-CH₃COCl.The very long chain fatty acids were separated on the SE-54 column.The ratio of C_24:0to C_22:0,C_26:0 to C_22:0 fatty acids was calculated.Abnormal ratios were observed in patient with ALD.The technique can be used for clinical diagnosis of ALD.

Key words: Very long chain fatty acids, Lipid, Plasma, Gas chromatography, Adrenoleucodystrophy

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ZHANG Shu-Feng, CHANG Li-Wen. Determination of Very Long Chain Fatty Acids in Plasma by Capillary Gas Chromatography[J]. Chem. J. Chinese Universities, 1994, 15(3): 364.

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Determination of Very Long Chain Fatty Acids in Plasma by Capillary Gas Chromatography

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