Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (4): 426.

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Studies on the Synthesis of Amino Acids(Ⅲ) --Phase-Transfer Catalytic Alkylations of N-Ethoxycarbonylmethyl Imidates

Shi Yaozeng, Shi Nongyuan, Sun Xiangzhen, Hu Hongwen   

  1. Department of Chemistry, Nanjing University, Nanjing
  • Received:1987-11-19 Online:1989-04-24 Published:1989-04-24

Abstract: Ethyl N-(ethoxycarbonylmethyl)benzenecarboximidate 1a and ethyl N-(ethoxycarbonylmethyl)ethanimidate 1b were alkylated under the solid-liquid PTCconditions by using solid K2CO3or KOH as a base and n-Bu4N+Br-as a phasetransfer catalyst. Subsequent hydrolysis furnished the corresponding a-amino acids.

Key words: Phase-transfer catalysis, Alkylation, Imidate, Amino acid

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