Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes

Abstract

Abstract: Ten 3-(arylmethyleneamino)propylsilatrane-metal complexes were synthesized by the reaction of metal salt with 3- (2-hydroxybenzylideneamino) propylsilatrane or 3-(2, 4-dihydroxyben-zylideneamino)propylsilatrane in methanol.The structure of these new complexes were identified by ¹H NMR, IRand elemental analysis.Animal screening data show that the inhibition ratio of bis-[N-(3-silatranylpropyl)-2-hydroxybenzylideneaminato] copper(Ⅱ) against Erlich ascites cancer in mice is 42.7%.

Key words: Antitumor activity, Schiff base, Metal complex, 2,8,9-Trioxa-5-aza-l-sila-bicyclo[3,3,3]-undecane

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Ding Qizhu, Luo Xuangan, Zhuo Renxi . Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes[J]. Chem. J. Chinese Universities, 1989, 10(12): 1254.

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Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes

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