Chemical Journal of Chinese Universities ›› 2014, Vol. 35 ›› Issue (10): 2146-2155.doi: 10.7503/cjcu20140393

• Physical Chemistry • Previous Articles     Next Articles

Theoretical Design and Experimental Performance Research on Barbital Imprinting Polymer

SU Tingting1, LIU Junbo1,*(), TANG Shanshan1, JIN Ruifa2   

  1. 1. College of Resources and Environment, Jilin Agricultural University, Changchun 130118
    2. College of Chemistry and Chemical Engineering, Chifeng University, Chifeng 024000
  • Received:2014-04-24 Online:2014-10-10 Published:2014-07-28
  • Contact: LIU Junbo E-mail:liujb@mail.ccut.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21302062), the Science and Technology Research Projects for Education Department of Jilin Province of China(No.201359) and the Science and Technology Developmental Plan of Jilin Province of China(No.20130206099SF)

Abstract:

On the basis of the density functional theory of M062X, we performed the interaction processes between the barbital(BAR) and different functional monomers by Gaussian 09 software. The functional monomers are methacrylic acid(MAA), acrylamide(AM), 4-vinylpyridine(4-Vpy), and N,N'-methylenebisa-crylamide(MBAD), respectively. The excellent functional monomer was optimized according to the hydrogen bond and binding energies(ΔE). The calculation results indicated that the number of hydrogen bonds was the largest, the bond length was the shortest, the ΔE was the lowest, and the interaction was the strongest between the MAA and the template molecule when the molar ratio of reaction for BAR-MAA was 1∶6. The molecular imprinted polymer microspheres(MIPs) composed of the BAR and MAA was synthesized by precipitation polymerization. The results showed that the stability and selective adsorption for MAA and BAR were the highest compared with the AM, 4-Vpy and MBAD. The average diameters of BAR-MIPs synthesized in acetonitrile was 190 nm. Analysis of the Scatchard plot revealed that the binding sites of BAR-MIPs to BAR were equal class under the studied concentration range, the dissociation constant(Kd) and apparent maximum adsorption quantity(Qmax) of BAR-MIPs were 63.3 mg/L and 17.5 mg/g, respectively. The thermodynamic study indicated that the adsorption of BAR-MIPs to BAR was an exothermic process, and the adsorption effect was better under the 293 K. The study of selective adsorption showed that BAR-MIPs had higher selectivity for BAR than that for 1,3-dimethyl barbituric acid(DMBA), 2-thiobarbituric acid(TMB), and pelltobarbitalum natricum(PBS). The studies can provide theoretical and experimental bases for the BAR molecular imprinted system, such as the selection of functional monomers, the optimization of reaction ratios, and the prediction of adsorption performance.

Key words: Barbital, Functional monomer, Molecular imprinting polymer, Simulation, Selective adsorption

CLC Number: