Microwave Assisted Solid-state Synthesis, Crystal Structure, Properties of the Coordination Polymer Constructed from Tricyclohexyltin Hydroxide and o-Ferrocenylcarbonyl Benzoic Acid†

doi:10.7503/cjcu20131282

Abstract

Abstract:

A novel coordination polymer tricyclohexyltin(o-ferrocenylcarbonyl) benzoate was synthesized by the reaction of tricyclohexyltin hydroxide with o-ferrocenylcarbonyl benzoic acid under microwave irradiation. It was characterized by UV, IR, ¹H and ¹³C NMR, elemental analysis and X-ray crystal diffraction. The crystal structure shows a distorted trigonal bipyramidal configuration with five-coordination for the central tin atom. The tin atoms and the oxygen atoms of C(O)—O and from the o-ferrocenylcarbonyl benzoate are interconnected to form a one-dimensional coordination polymer chain. The thermal studies showed that complex exhibited higher thermal stability. Electrochemical studies of the complex have been made in EtOH/H₂O by cyclic voltammetry. The complex shows quasi reversible electron transfer process. The in vitro antitumour activity of the complex was tested.The results show that the complex exhibits better antitumour activity in vitro against HT-29, MCF-7, HepG2, KB and A549 tumour cells. So the complex may have potential applications.

Key words: Coordination polymer, Crystal structure, Electrochemical property, Thermal stability, Anticancer activity

CLC Number:

O614.43⁺2

TrendMD:

KUANG Daizhi, FENG Yonglan, YU Jiangxi, ZHANG Fuxing, JIANG Wujiu, PENG Yan, ZHU Xiaoming, TAN Yuxing. Microwave Assisted Solid-state Synthesis, Crystal Structure, Properties of the Coordination Polymer Constructed from Tricyclohexyltin Hydroxide and o-Ferrocenylcarbonyl Benzoic Acid^†[J]. Chem. J. Chinese Universities, 2014, 35(8): 1629.

Figures/Tables 5

Table 1 Selected bond lengths(nm) and bond angles(°) of the complex*

Sn1—C1	0.2155(4)	Sn1—C7	0.2146(4)	Sn1—C13	0.2159(4)
Sn1—O1^#	0.2126(2)	Sn1—O3	0.2651
O1^#—Sn1—C1	96.69(15)	O1^#—Sn1—C7	104.70(12)	O1^#—Sn1—C13	92.09(14)
C7—Sn1—C1	124.06(17)	C1—Sn1—C13	116.48(19)	C7—Sn1—C13	113.69(17)
O3—Sn1—C1	82.45	O3—Sn1—C7	83.35	O3—Sn1—C13	79.98
O1^#—Sn1—O3	170.53

Fig.1 Molecular structure of the complex H atoms are omitted for clarity. #: -x+2, y-1/2, -z+1/2.

Fig.2 1D polymeric structure of the complex Cyclohexyl groups are omitted for clarity.

Fig.3 2D supramolecular structure of the complex by C—H…π interactions C34#—H34#…π(C20—C25) 0.3555 nm, #: 1-x, 1-y, -z. Cyclohexyl groups are omitted for clarity.

Table 2 IC50 values of the complex and cis-platin on HepG2, KB, MCF-7, A549 and HT-29

Sample	IC₅₀/(μmol·L^-1)
Sample	HepG2	KB	MCF-7	A549	HT-29
Complex	0.298	0.935	0.293	1.008	0.079
cis-Platin	65.32	2.650	88.17	1.510	58.06

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