高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

含哌啶取代酞菁金属配合物的合成及其对癌细胞光灭活作用

黄紫洋1,2, 薛金萍1, 陈锦灿3, 陈耐生1, 黄金陵1   

    1. 福州大学功能材料研究所, 福州 350002;
    2. 福建师范大学化学与材料学院, 福州 350007;
    3. 中国科学院福建物质结构研究所, 福州 350002
  • 收稿日期:2007-08-20 修回日期:1900-01-01 出版日期:2008-03-10 发布日期:2008-03-10
  • 通讯作者: 黄金陵

Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell

HUANG Zi-Yang1,2, XUE Jin-Ping1, CHEN Jin-Can3, CHEN Nai-Sheng1, HUANG Jin-Ling1*   

    1. Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China;
    2. College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;
    3. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
  • Received:2007-08-20 Revised:1900-01-01 Online:2008-03-10 Published:2008-03-10
  • Contact: HUANG Jin-Ling

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被引次数

13

摘要： 采用“模板法”合成8种含哌啶取代酞菁金属配合物[(PEO)4PcM, M=Zn, Ni, Co, Cu, PEO=2-(哌啶-1-基)乙氧基], 采用FTIR、质谱和元素分析等技术对其进行了表征. 分别测定了它们的紫外-可见吸收光谱、荧光发射光谱和光敏化产生单线态氧的能力. 研究结果表明, 2种酞菁锌配合物均具有较高的摩尔消光系数、一定的荧光量子产率和较大的单线态氧生成速率. 通过光动力灭活BEL7402肝癌细胞的试验研究发现, β-(PEO)4PcZn的浓度为10 μmol/L时, 在670 nm激光辐照下, 光剂量为1.2 J时, 对癌细胞的抑制率可达到83%.

关键词: 酞菁金属配合物, N-哌啶乙醇, 合成, 光灭活作用

Abstract: “The template approach” was used for the synthesis of eight metal phthalocyanine complexes containing piperidine group(PEO)4PcM, where M=Zn, Ni, Co, Cu, PEO=2-(piperidin-1-yl) ethyoxyl. These complexes were characterized by FTIR, mass spectrum, elemental analysis and so on. The UV-Vis absorption spectra, fluorescence emission spectra and capacity of photo-generating singlet oxygen were examined. The results showed that two zinc phthalocyanine complexes possessed high molar extinction coefficient, fluorescence quantum yield, high rate of photo-generating singlet oxygen. The complex with formula β-(PEO)4PcZn had a photoinhibition effect to BEL7402 liver cancer cells up to 83% in case that the irradiation with 670 nm laser light(dosage 1.2 J) and the concentration of β-(PEO)4PcZn with 10 μmol/L were used.

Key words: Metal phthalocyanine, N-Piperidineethanol, Synthesis, Photoinhibition

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