高等学校化学学报

高等学校化学学报

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微波聚合快速制备分子印迹毛细管电色谱整体柱

张裕平1, 左国强2, 许光日1, 李全民2, 袁倬斌1,3   

    1. 河南科技学院应用化学研究所, 新乡 453003;
    2. 河南师范大学化学系, 新乡 453007;
    3. 中国科学院研究生院, 北京 100039
  • 收稿日期:2007-04-09 修回日期:1900-01-01 出版日期:2007-09-10 发布日期:2007-09-10
  • 通讯作者: 张裕平

Rapid Preparation of Molecularly Imprinted Capillary Monolithic Columns by Microwave Polymerization

ZHANG Yu-Ping1*, ZUO Guo-Qiang2, XU Guang-Ri1, LI Quan-Min2, YUAN Zhuo-Bin1,3   

    1. Institute of Applied Chemistry, Henan Institute of Science and Technology, Xinxiang 453003, China;
    2. Department of Chemistry, Henan Normal University, Xinxiang 453007, China;
    3. Graduate School, Chinese Academy of Sciences, Beijing 100039, China
  • Received:2007-04-09 Revised:1900-01-01 Online:2007-09-10 Published:2007-09-10
  • Contact: ZHANG Yu-Ping

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被引次数

41

摘要： 以甲基丙烯酸为功能单体、己二醇二甲基丙烯酸酯为交联剂、 对羟基苯甲酸为模板分子, 采用微波辐射聚合的方式快速制备了分子印迹毛细管电色谱整体柱, 并取得了较好的印迹效果. 分子印迹材料的原位制备5 min即可完成, 大大快于国内外传统的方法.

关键词: 微波, 分子印迹聚合物, 整体柱, 毛细管电色谱

Abstract: Microwave irradiation was firstly attempted to prepare molecularly imprinted polymers (MIPs) monoliths, which were in situ prepared rapidly with methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EDMA) as a cross-linking agent, toluene and isooctane as the porogenic solvents and AIBN as an initiator. The baseline separation of isomers of hydroxybenzoic acid was achieved on these monolithic columns with 4-HBA as the template, but not on the blank polymer. Furthermore, some neutral compounds could also be baseline-separated on the imprinted polymer columns in the modes of pressure-driven capillary electrochromatography and low-pressure driven capillary electrochromatography. It was shown that the monoliths were not only used as the molecularly imprinted polymers but also as the reverse phase chromatographic material.

Key words: Microwave, Molecularly imprinted polymer, Monolithic column, Electrochromatography

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