高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (12): 2749-2758.doi: 10.7503/cjcu20200563

• 有机化学 • 上一篇    下一篇

微波辅助无催化剂高效串联环化合成吡啶[2,3⁃d]嘧啶衍生物

林俊洁, 王爽, 李伟强, 崔鑫, 黄超()   

  1. 云南民族大学化学与环境学院,昆明 650503
  • 收稿日期:2020-08-14 出版日期:2020-12-10 发布日期:2020-12-09
  • 通讯作者: 黄超 E-mail:huangchao@ynu.edu.cn
  • 基金资助:
    国家自然科学基金(21662046)

Efficient Synthesis of Pyridine [2,3-d]pyrimidine Derivatives by Catalyst-free Tandem Cyclization Under Microwave Irradiation

LIN Junjie, WANG Shuang, LI Weiqiang, CUI Xin, HUANG Chao()   

  1. School of Chemistry and Environment,Yunnan Minzu University,Kunming 650503,China
  • Received:2020-08-14 Online:2020-12-10 Published:2020-12-09
  • Contact: HUANG Chao E-mail:huangchao@ynu.edu.cn
  • Supported by:
    ? Supported by the National Natural Science Foundation of China(21662046)

摘要:

建立了一种吡啶[2,3-d]嘧啶类化合物的高效合成方法. 以α,β?不饱和酮类化合物和1,3-二甲基-6-氨基脲嘧啶为原料, 在微波辅助无催化剂条件下, 于5~15 min内高效串联环化合成了28个具有分子多样性的吡啶[2,3-d]嘧啶类化合物, 其中21个化合物未见文献报道. 该方法具有原料简单易得、 高效绿色、 成键效率高及后处理简单等优点.

关键词: α,β-不饱和酮, 吡啶[2,3-d]嘧啶, 微波辅助, 无催化剂, 串联环化

Abstract:

This work presents a highly efficient and simple method for the synthesis of pyridine [2,3-d] pyrimidine derivatives. This method took the α,β-unsaturated ketones compounds and 1,3-dimethyl-6-aminouracil as raw material, 28 pyridine [2,3-d]pyrimidine derivatives were synthesized by microwave irradiation high-efficiency tandem cyclization in 5―15 min without catalyst, including 21 compounds did not see the literature. This method has the characteristics of simple and easy raw materials, high green efficiency, high bonding efficiency and simple post-treatment.

Key words: α, β-Unsaturated ketone, Pyridine [2, 3-d]pyrimidine, Microwave irradiation, Catalyst-free, Tandem cyclization

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