高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (11): 1742.

• 论文 • 上一篇    下一篇

天然产物Epibatidine的作用受体初探

徐建平1, 何东1, 王志中2, 沈家骢1, 高连勋3, 宋雅茹4   

  1. 1. 吉林大学化学系, 长春, 130023;
    2. 吉林大学理论化学研究所, 长春, 130023;
    3. 中国科学院长春应用化学研究所;
    4. 北京师范大学化学系
  • 收稿日期:1995-11-29 出版日期:1996-11-24 发布日期:1996-11-24
  • 通讯作者: 徐建平,男,31岁,博士,讲师.
  • 作者简介:徐建平,男,31岁,博士,讲师.
  • 基金资助:

    吉林省科学技术委员会青年基金

Studies on Action Receptor to Natural Product Epibatidine

XU Jian-Ping1, HE Dong1, WANG Zhi-Zhong2, SHEN Jia-Cong1, GAO Lian-Xun3, SONG Ya-Ru4   

  1. 1. Department of Chemistry, Jilin University, Changchun, 130023;
    2. Institute of Theoretical Chemistry, Jilin University, Changchun, 130023;
    3. Changchun Institute of Applied Chemistry;
    4. Dept. of Chem., Bejing Normal University, Beijing
  • Received:1995-11-29 Online:1996-11-24 Published:1996-11-24

PDF (PC)

被引次数

1

关键词: Epibatidine, 尼古丁, 受体, AM1

Abstract: According to the theoretical calculation of epibatidine and nicotine by using AM1 method,we made a good explaination for the phenomenon that the analgetic action of epibatidine doesn't be reversed by naloxone as usual analgetics for the first time,and this result supports the results of Daly's experiment.In addition,as epibatidine and micotine have many similarities such as structure,activity and other qualities,so we believe that they also have the same action receptor-nicotine receptor.

Key words: Epibatidine, Nicotine, Action receptor, AM1

TrendMD: