高等学校化学学报 ›› 2017, Vol. 38 ›› Issue (9): 1512-1517.doi: 10.7503/cjcu20170286

• 研究论文: 无机化学 • 上一篇    下一篇

Ag∶InP/ZnSe纳米晶的合成与生物成像

亢艳艳2, 戚卉1, 周淼2, 张颖2, 庄家琪2, 杨军星1, 王博蔚1   

  1. 1吉林大学第二医院, 长春 130021
    2. 吉林大学化学学院, 长春 130012
  • 出版日期:2017-09-10 发布日期:2017-08-17
  • 作者简介:联系人简介: 王博蔚, 女, 博士, 副主任医师, 主要从事妇产科学及相关医学生物成像方面的研究. E|mail: wangbowei2009@hotmail.com
  • 基金资助:
    吉林省医药产业推进计划项目(批准号: 20140311088YY, 201603028YY)、 吉林省科技攻关计划项目(批准号: 20150204004YY)和长春市“双十工程”计划项目(批准号: 16SS12)资助

Synthesis of Ag∶InP/ZnSe Nanocrystals and Their Application in Bioimaging

KANG Yanyan2, QI Hui1, ZHOU Miao2, ZHANG Ying2, ZHUANG Jiaqi2, YANG Junxing1, WANG Bowei1,*   

  1. (1. The Second Hospital of Jilin University, Changchun 130021, China
    2. College of Chemistry, Jilin University, Changchun 130012, China)
  • Online:2017-09-10 Published:2017-08-17
  • Contact: WANG Bowei

摘要:

采用高温热注入法, 以P[N(CH3)2]3为磷源合成了具有近红外荧光的Ag∶InP/ZnSe纳米晶. 采用紫外|可见|近红外吸收光谱(UV|Vis|NIR)、 荧光光谱、 透射电子显微镜(TEM)、 X 射线衍射(XRD)等对产物的结构和光学性质进行了表征, 并分析了Ag掺杂浓度和温度对InP纳米晶荧光性能的影响. 通过调节Ag掺杂浓度和反应温度, 发现当Ag掺杂量为6%, 反应温度为200 ℃时, Ag∶InP纳米晶的发光效率最高. 将制备的Ag∶InP的表面包覆ZnSe, 粒子的荧光效率从原来的20%提高到45%. 将具有近红外荧光的Ag∶InP/ZnSe纳米晶应用于细胞成像, 结果表明制备的荧光纳米晶在细胞成像中清晰可见且毒性较低.

关键词: Ag∶InP/ZnSe, 纳米晶, 近红外荧光, 生物成像

Abstract:

Ag∶InP nanocrystals with near|infrared(NIR) luminescence properties were synthesized and characterized by means of UV|Vis|NIR absorption spectroscopy, transmission electron microscopy(TEM) and X|ray powder diffraction(XRD). When Ag doping amount was 6% and doping temperature was 200 ℃, the Ag∶InP nanocrystals have the highest luminous efficiency. The emission of as|prepared samples was tunable in the near infrared region by tuning the size of samples. After the surface of Ag∶InP nanocrystals was coated with ZnSe, the stability of the particles was improved, and the fluorescence efficiency of the particles was increased from 20% to 45%. Also, the biomedical imaging results indicated that as|prepared Ag∶InP/ZnS nanocrystals could be a nice carrier with low toxicity.

Key words: Ag∶InP/ZnSe, Nanocrystals, Near, infrared luminescence, Bioimaging

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