高等学校化学学报

高等学校化学学报

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用于研究病毒唑作用机理的光敏探针的设计与合成

朱洵1, 2, 曲凡歧3   

  1. 1. 北京大学天然药物与仿生药物国家重点实验室, 北京 100083;
    2. 武汉化工学院材料科学与工程学院, 武汉 430074;
    3. 武汉大学化学与分子科学学院, 武汉 430072
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-06-10 发布日期:2006-06-10
  • 通讯作者: 朱洵

Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin

ZHU Xun1,2*, QU Fan-Qi3   

  1. 1. The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China;
    2. School of Material Science and Engineering, Wuhan Institute of Chemical Technology, Wuhan 430074, China;
    3. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-06-10 Published:2006-06-10
  • Contact: ZHU Xun

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被引次数

6

摘要： 对用于研究病毒唑作用机理的光敏探针进行了设计, 并以四乙酰核糖化合物和3-溴-1,2,4-三唑-5-酰甲酯化合物为原料进行合成实验, 得到光敏探针化合物5-叠氮基-1-(β-呋喃核糖基)1,2,4-三唑-3-酰胺和3-叠氮基-1-(β-呋喃核糖基)-1,2,4-三唑-5-酰胺. 采用IR, MS和1 H NMR等技术对化合物的结构进行了表征, 同时对探针分子的设计和结构判定进行了探讨.

关键词: 病毒唑, 光敏探针, 三唑叠氮化合物, 设计, 合成

Abstract: The photolabeling probes for the study of antiviral mechanism of ribavirin were designed, and the synthesis experiments were carried out by using 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and methyl 3-bromo-1,2,4-triazole-5-carboxylate as the raw materials. Two photolabeling probes for the study of antiviral mechanism of ribavirin, 5-azido-1-(β-ribofuranosyl)-1,2,4-triazole-3-carboxamide and 3-azido-1-(β-ribofuranosyl)-1,2,4-triazole-5-carboxamide were synthesized, and characterized by IR, MS and 1H NMR, etc.. The design of the photolabeling probes and their structures were discussed.

Key words: Ribavirin, Photolabeling probe, Aizdotriazoles, Design, Synthesis

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