石墨烯/聚吡咯的添加对磷酸钙骨水泥结构与性能的影响

doi:10.7503/cjcu20150417

高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (12): 2598.doi: 10.7503/cjcu20150417

石墨烯/聚吡咯的添加对磷酸钙骨水泥结构与性能的影响

肖镇昆, 于浩然, 吴涛, 王瑞贞, 彭章, 卢晓英(), 翁杰

材料先进技术教育部重点实验室, 西南交通大学材料科学与工程学院, 成都 610031

收稿日期:2015-05-22 出版日期:2015-12-10 发布日期:2015-11-17
作者简介:联系人简介: 卢晓英, 女, 博士, 副教授, 主要从事生物材料研究. E-mail:luxy2005@swjtu.com
基金资助:
国家“九七三”计划项目(批准号: 2012CB933602)、国家自然科学基金(批准号: 51172188)和西南交通大学重点实验室开放项目(批准号: ZD20145014)资助

Effects of Adding Reduced-graphene Oxide/Polypyrrole Composites on the Structure and Properties of Calcium Phosphate Cement^†

XIAO Zhenkun, YU Haoran, WU Tao, WANG Ruizhen, PENG Zhang, LU Xiaoying^*(), WENG Jie

Key Lab of Advanced Materials Technology of Ministry of Education, School of Material Science & Engineering, Southwest Jiaotong University, Chengdu 610031, China

Received:2015-05-22 Online:2015-12-10 Published:2015-11-17
Contact: LU Xiaoying E-mail:luxy2005@swjtu.com
Supported by:
† Supported by the National Basic Research Program of China(No.2012CB933602), the National Natural Science Foundation of China(No.51172188) and the Open Project of Key Laboratory, Southwest Jiaotong University, China(No.ZD20145014)

摘要/Abstract

摘要：

自然骨具有压电效应, 结合电刺激可以促进骨组织生长与修复, 因此制备具有导电性人工骨材料尤为重要. 本文通过在骨水泥(CPC)固相中添加不同含量的高导电率的还原氧化石墨烯(RGO)/聚吡咯(PPy)复合材料, 研究不同含量RGO/PPy的添加对CPC结构与性能的影响. 结果表明, 添加RGO/PPy复合材料的CPC, 其初凝时间和终凝时间都有所减小, 但凝固时间均能满足临床使用要求. RGO/PPy的添加对CPC的物相组成没有影响, 但对其抗压力学性能、微观形貌、导电性能的影响较大. 其中, CPC的抗压力学性能随着RGO/PPy添加量的增加而减小, 导电性随着RGO/PPy的添加量的增加而增大.

关键词: 聚吡咯, 石墨烯, 磷酸钙骨水泥, 电导率, 力学性能

Abstract:

With the piezoelectricity of natural bone, electrical stimulation has been widely used in clinic for promoting bone growth and reconstruction. It has special meaning to prepare a conductive biomaterial for bone repair. In this paper, reduced-graphene oxide(RGO)/polypyrrole(PPy) composites with high conducity were added in the solid phase of calcium phosphate cement(CPC) and the effect of this addition on the structure and properties was investigated. The composites had great impact on physicochemical properties of CPC. The results showed that the setting time of CPC significantly decreases with RGO/PPy adding. It has great influence of adding RGO/PPy on the mechanical properties and conductivity of CPC, but no obvious effect on the phase composition of CPC. The conductivity of CPC gradually increases with the increase of RGO/PPy adding amount, and the compressive properties show opposite results with RGO/PPy addition. It has a dependent relationship between the adding amount of RGO/PPy and the conductivity and compressive mechanical properties.

Key words: Polypyrrole, Reduced-graphene oxide, Calcium phosphate cement, Conductivity, Mechanical property

中图分类号:

O633

TrendMD:

肖镇昆, 于浩然, 吴涛, 王瑞贞, 彭章, 卢晓英, 翁杰. 石墨烯/聚吡咯的添加对磷酸钙骨水泥结构与性能的影响. 高等学校化学学报, 2015, 36(12): 2598.

XIAO Zhenkun, YU Haoran, WU Tao, WANG Ruizhen, PENG Zhang, LU Xiaoying, WENG Jie. Effects of Adding Reduced-graphene Oxide/Polypyrrole Composites on the Structure and Properties of Calcium Phosphate Cement^†. Chem. J. Chinese Universities, 2015, 36(12): 2598.

图/表 9

Table 1 Formula of preparation of CPC

Sample	Mass fraction of solid phase(%)							Liquid to solid ratio/(mL·g^-1)
Sample	HA	β-TCP	DCPD	CaCO₃	MgO	CS	RGO/PPy	Liquid to solid ratio/(mL·g^-1)
CPC-blank	7.7	52.2	22.5	5.4	2.25	10.0	0	0.5
CPC-PR6	7.2	49.1	21.1	5.1	2.1	9.4	6.0	0.7
CPC-PR8	7.0	48.0	20.7	5.0	2.1	9.2	8.0	0.8
CPC-PR10	6.9	47.0	20.2	4.9	2.0	9.0	10.0	0.9
CPC-PR12	6.7	45.9	19.8	4.8	2.0	8.8	12.0	1.0

Fig.1 Initial(A) and final setting time(B) of CPC samples a. CPC-blank; b. CPC-PR6; c. CPC-PR8; d. CPC-PR10; e. CPC-PR12.

Fig.2 XRD patterns of CPC samples a. PPy/RGD; b. CPC-blank; c. CPC-PR6; d. CPC-PR8;e. CPC-PR10; f. CPC-PR12.

Table 2 Crystallinity of CPC

Sample	CPC-blank	CPC-PR6	CPC-PR8	CPC-PR10	CPC-PR12
X_c(%)	43.2	47.3	54.4	59.8	63.7

Fig.3 Conductivity and sheet resistance of CPC samples

Fig.4 Stress-strain curves of CPC samples a. CPC-blank; b. CPC-PR6; c. CPC-PR8;d. CPC-PR10; e. CPC-PR12.

Fig.5 Compressive strength(A) and elastic modulus(B) of CPC samples a. CPC-blank; b. CPC-PR6; c. CPC-PR8;d. CPC-PR10; e. CPC-PR12.

Fig.6 Porosity of different CPC samples a. CPC-blank; b. CPC-PR6; c. CPC-PR8;d. CPC-PR10; e. CPC-PR12.

Fig.7 SEM images of the fracture surface of CPC (A) RGO/PPy; (B) CPC-blank; (C) CPC-PR6; (D) CPC-PR8; (E) CPC-PR10; (F) CPC-PR12.

参考文献 36

[1]	Theiss F., Apelt D., Brand B., Kutter A., Zlinszky K., Bohner M., Matter S., Frei C., Auer J. A., Rechenberg B., Biomaterials, 2005, 26(21), 4383—4394
[2]	Alge D. L., Chu T. M. G., J. Biomed. Mater. Res. A, 2010, 94(2), 547—555
[3]	Cai Z. Y., Yang D. A., Zhang N., Ji C. G., Zhu L., Zhang T., Acta Biomater., 2009, 5(2), 628—635
[4]	Cai Z., Zhang T., Di L., Xu D. M., Xu D. H., Yang D. A., Biomed. Microdevices,2011, 13(4), 623—631
[5]	Li D., Yang Z., Li X., Li Z., Li J., Yang J., Biomed. Mater., 2010, 5(2), 025007
[6]	Paterson D. C., Lewis G. N., Cass C. A., Clin. Orthop. Relat. Res., 1980, 148, 117—128
[7]	Wong J. Y., Langer R., Ingber D. E., Proc. Natl. Acad. Sci. USA, 1994, 91(8), 3201—3204
[8]	Williams R. L., Doherty P. J., J. Mater. Sci. Mater. Med., 1994, 5(6/7), 429—433
[9]	Lakard B., Ploux L., Anselme K., Lallemand F., Lakard S., Nardin M., Hihn J. Y., Bioelectrochemistry, 2009, 75(2), 148—157
[10]	Novoselov K. S., Fal V. I., Colombo L., Gellert P. R., Schwab M. G., Kim K., Nature, 2012, 490(7419), 192—200
[11]	Chen J., Liu H., Zhao C., Qin G., Xi G., Li T., Wang X., Chen T., Biomaterials, 2014, 35(18), 4986—4995
[12]	Hu W., Peng C., Luo W., Lv M., Li X., Li D., Huang Q., Fan C., ACS Nano,2010, 4(7), 4317—4323
[13]	Peng Z., Preparation of Reduced-Graphene Oxide/Polypyrrole Composite and Its Application in Calcium Phosphate Cement, Southwest Jiaotong University, Chengdu, 2015
	(彭章. 石墨烯/聚吡咯复合材料的制备及在磷酸钙骨水泥中的应用, 成都: 西南交通大学, 2015)
[14]	Zhou Y., Bao Q., Tang L. A. L., Zhong Y., Loh K. P., Chem. Mater., 2009, 21(13), 2950—2956
[15]	Chae H. K., Siberio-Pérez D. Y., Kim J., Go Y. B., Eddaoudi M., Matzger A. J., O’Keeffe M., Yaghi O. M., Nature, 2004, 427(6974), 523—527
[16]	Khairoun I., Driessens F. C. M., Boltong M. G., Planell J. A., Wenz R., Biomaterials, 1999, 20(4), 393—398
[17]	Liu Q., Hu Y. F., Xiong J. J., Lubri. Engi., 2010, 35(10), 99—101
	(刘颀, 胡亚非, 熊建军. 润滑与密封, 2010, 35(10), 99—101)
[18]	Khairoun I., Boltong M. G., Driessens F. C. M., Planell J. A., J. Biomed. Mater. Res. A, 1997, 38(4), 356—360
[19]	Shen J., Hu Y., Shi M., Lu X., Qin C., Li C., Ye M., Chem. Mater., 2009, 21(15), 3514—3520
[20]	Lu G., Li C., Shi G., Polymer, 2006, 47(6), 1778—1784
[21]	Pang Y. X., Bao X., J. Eur. Ceram. Soc., 2003, 23(10), 1697—1704
[22]	Jakubiec B., Marois Y., Zhang Z., Roy R., Sigot-Luizard M. F., Dugré F. J., King M. W., Dao L., Laroche G., Guidoin R., J. Biomed. Mater. Res. A, 1998, 41(4), 519—526
[23]	Qiu T., Huang J. J., Zhang M., Wang X. F., Li C., Lu X. Y., Weng J., J. Inorg. Mater., 2013, 28(1), 91—96
	(邱添, 黄静静, 张苗, 王先福, 李辰, 卢晓英, 翁杰. 无机材料学报, 2013, 28(1), 91—96)
[24]	Sun X.N., Study on the Setting Mechanism of CNTs/Calcium Phosphate Cement Composite, Shandong University, Jinan, 2007
	(孙晓宁. CNTs/磷酸钙骨水泥复合材料的快速凝固成型及机理研究, 济南: 山东大学, 2007)
[25]	Chabot V., Kim B., Sloper B., Tzoganakis C., Yu A., Sci. Rep., 2013, 3, 1378
[26]	Guo Y., Li M., Mylonakis A., Han J., MacDiarmid A. G., Chen X., Lelkes P. I., Wei Y., Biomacromolecules, 2007, 8(10), 3025—3034
[27]	Janata J., Josowicz M., Nat. Mater., 2003, 2(1), 19—24
[28]	Bettinger C. J., Bruggeman J. P., Misra A., Borenstein J. T., Langer R., Biomaterials, 2009, 30(17), 3050—3057
[29]	George P. M., Saigal R., Lawlor M. W., Moore M. J., LaVan D. A., Marini R. P., Selig M., Makhni M., Burdick J. A., Langer R., Kohane D. S., J. Biomed. Mater. Res. A, 2009, 91(2), 519—527
[30]	Lee J. Y., Bashur C. A., Goldstein A. S., Schmidt C. E., Biomaterials, 2009, 30(26), 4325—4335
[31]	Shi G., Rouabhia M., Meng S., Zhang Z., J. Biomed. Mater. Res. A, 2008, 84(4), 1026—1037
[32]	Huang J., Hu X., Lu L., Ye Z., Zhang Q., Luo Z., J. Biomed. Mater. Res. A, 2010, 93(1), 164—174
[33]	Zhao J. S., Qu S. X., Huang P., Liu Z. G., Wang S. W., Weng J., J. Inorg. Mater., 2015, 30(3), 318—324
	(赵军胜, 屈树新, 黄萍, 刘宗光, 王铈汶, 翁杰. 无机材料学报, 2015, 30(3), 318—324)
[34]	Han B., Ma P. W., Zhang L. L., Yin Y. J., Yao K. D., Zhang F. J., Zhang Y. D., Li X. L., Nie W., Acta Biomater., 2009, 5(8), 3165—3177
[35]	Galea L. G., Bohner M., Lemaître J., Kohler T., Müller R., Biomaterials, 2008, 29(24), 3400—3407
[36]	Barralet J. E., Grover L. M., Gbureck U., Biomaterials, 2004, 25(11), 2197—2203

石墨烯/聚吡咯的添加对磷酸钙骨水泥结构与性能的影响

Effects of Adding Reduced-graphene Oxide/Polypyrrole Composites on the Structure and Properties of Calcium Phosphate Cement^†

RichHTML

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

图/表 9

参考文献 36

相关文章 15

编辑推荐

Metrics

本文评价

[1]	王瑞娜, 孙瑞粉, 钟添华, 池毓务. 大尺寸石墨烯量子点组装体的制备及电化学发光性能[J]. 高等学校化学学报, 2022, 43(8): 20220161.
[2]	骆鑫妍, 贾若男, 向勇, 张晓琨. 可拉伸聚合物基复合固体电解质研究进展[J]. 高等学校化学学报, 2022, 43(8): 20220149.
[3]	刘树威, 晋皓, 尹万忠, 张皓. 用于卵巢癌化疗-光热联合治疗的吉西他滨/聚吡咯复合纳米粒子[J]. 高等学校化学学报, 2022, 43(8): 20220345.
[4]	闫嘉森, 韩现英, 党兆涵, 李建刚, 何向明. 石蜡/膨胀石墨/石墨烯复合相变储热材料的制备及性能[J]. 高等学校化学学报, 2022, 43(6): 20220054.
[5]	曹磊, 陈美君, 袁刚, 常钢, 张修华, 王升富, 何汉平. 冠醚功能化的栅控石墨烯场效应晶体管的制备及对汞离子的检测[J]. 高等学校化学学报, 2022, 43(4): 20210688.
[6]	郑雪莲, 杨翠翠, 田维全. 全椅式边含薁缺陷石墨烯纳米片的二阶非线性光学性质[J]. 高等学校化学学报, 2022, 43(3): 20210806.
[7]	杨隽阁, 高成乾, 李博鑫, 尹德忠. 改性氧化石墨烯稳定Pickering乳液法制备高导热相变整体材料[J]. 高等学校化学学报, 2022, 43(2): 20210593.
[8]	张志博, 尚涵, 徐文轩, 韩广东, 崔金声, 杨皓然, 李瑞鑫, 张生辉, 徐欢. 氧化石墨烯插层聚β-羟基丁酸酯复合材料的结晶形态与宏观性能[J]. 高等学校化学学报, 2022, 43(2): 20210566.
[9]	胡波, 朱昊辰. 双层氧化石墨烯纳米体系中受限水的介电常数[J]. 高等学校化学学报, 2022, 43(2): 20210614.
[10]	俞彬, 谌小燕, 赵越, 陈卫昌, 肖新颜, 刘海洋. 氧化石墨烯基钴卟啉复合材料的电催化析氢反应[J]. 高等学校化学学报, 2022, 43(2): 20210549.
[11]	王雪丽, 宋相伟, 解颜宁, 杜妮阳, 王振新. 部分还原氧化石墨烯的制备、表征及对人宫颈癌HeLa细胞的体外杀伤作用[J]. 高等学校化学学报, 2022, 43(2): 20210595.
[12]	徐欢, 柯律, 唐梦珂, 尚涵, 徐文轩, 张子林, 付亚男, 韩广东, 崔金声, 杨皓然, 高杰峰, 张生辉, 何新建. 液相剪切原位剥离蒙脱土纳米片增强高阻氧聚乳酸[J]. 高等学校化学学报, 2022, 43(11): 20220316.
[13]	马丽娟, 高升启, 荣祎斐, 贾建峰, 武海顺. Sc, Ti, V修饰B/N掺杂单缺陷石墨烯的储氢研究[J]. 高等学校化学学报, 2021, 42(9): 2842.
[14]	朱德帅, 赵剑英, 杨正慧, 郭海泉, 高连勋. 基于多层结构设计的高储能密度氧化石墨烯/聚酰亚胺复合材料[J]. 高等学校化学学报, 2021, 42(8): 2694.
[15]	黄珊, 姚建东, 宁淦, 肖琦, 刘义. 石墨烯量子点荧光探针对碱性磷酸酶活性的高效检测[J]. 高等学校化学学报, 2021, 42(8): 2412.

石墨烯/聚吡咯的添加对磷酸钙骨水泥结构与性能的影响

Effects of Adding Reduced-graphene Oxide/Polypyrrole Composites on the Structure and Properties of Calcium Phosphate Cement†

RichHTML

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

图/表 9

参考文献 36

相关文章 15

编辑推荐

Metrics

本文评价

Effects of Adding Reduced-graphene Oxide/Polypyrrole Composites on the Structure and Properties of Calcium Phosphate Cement^†