三聚氰胺甲醛微球的制备及模板法构建聚谷氨酸基微胶囊

高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (10): 2447.

三聚氰胺甲醛微球的制备及模板法构建聚谷氨酸基微胶囊

张瑛¹,颜世峰¹,饶水琴¹,郑嬿珍¹,尹静波¹,陈学思²

1. 上海大学高分子材料系, 上海 201800;
2. 中国科学院长春应用化学研究所, 高分子物理与化学国家重点实验室, 长春 130022

收稿日期:2010-10-13 修回日期:2011-01-10 出版日期:2011-10-10 发布日期:2011-09-11
通讯作者: 尹静波;陈学思 E-mail:jbyin@shu.edu.cn;xschen@ciac.jl.cn
基金资助:
国家自然科学基金(批准号: 51003055, 50973060)、上海市教育委员会科研创新项目(批准号: 11YZ06)和上海市重点学科项目(批准号: s30107)资助.

Preparation of Melamine-formaldehyde Microspheres and Microcapsules Based on Poly(glutamic acid) by Template Method

ZHANG Ying¹, YAN Shi-Feng¹, RAO Shui-Qin¹, ZHENG Yan-Zhen¹, YIN Jing-Bo^1*, CHEN Xue-Si^2*

1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2010-10-13 Revised:2011-01-10 Online:2011-10-10 Published:2011-09-11
Contact: YIN Jing-Bo;CHEN Xue-Si E-mail:jbyin@shu.edu.cn;xschen@ciac.jl.cn
Supported by:
国家自然科学基金(批准号: 51003055, 50973060)、上海市教育委员会科研创新项目(批准号: 11YZ06)和上海市重点学科项目(批准号: s30107)资助.

摘要/Abstract

摘要： 以分散聚合法制备低交联度三聚氰胺甲醛(MF)微球, 研究了pH和反应时间等对MF微球粒径、表面电位和溶解性的影响. 以MF微球为模板, 采用层层自组装法交替吸附聚谷氨酸(PGA)和壳聚糖(CS), 构建中空的PGA/CS微胶囊. 采用偏光显微镜、纳米粒度及电位分析仪、红外和透射电镜等进行表征. 结果表明, MF粒径及表面电位随pH值降低而减小, 在盐酸中的溶解性随反应时间延长而变差. 在自组装过程中, 微球表面电位呈正负交替变化, 表明以静电力为主要驱动力制得的空心微胶囊粒径均匀, 分散良好, 模型药物罗丹明可成功载入其中, 有望成为优良的水溶性药物载体.

关键词: 三聚氰胺甲醛微球, 聚谷氨酸, 微胶囊, 自组装, ζ电位

Abstract: Melamine-formaldehyde (MF) microspheres were prepared by dispersion polymerization. The influences of pH value and reaction time on partical size, surface potential and solubility of MF microspheres were studied. Using MF microspheres as templates, hollow PGA/CS microcapsules were fabricated by layer-by-layer technique. The templates and microcapsules were characterized by polarization microscope, nano-granularity and potential analyzer, IR and TEM. The results show that the partical size and surface potential of MF microspheres decrease with the reducing of pH and its solubility in hydrochloric acid becomes worse as the time grows. The main driving force is electrostatic force between PGA and CS, which is supported by alternating ζ-potentials. The hollow microcapsules with uniform size and good dispersity shows successful loading of model drug rhodamine, which is expected to find application in excellent carriers of water-soluble drugs.

Key words: Melamine-formaldehyde(MF), Poly(glutamic acid), Microcapsule, Assembly technique, ζ-potential

中图分类号:

O631

TrendMD:

张瑛颜世峰饶水琴郑嬿珍尹静波陈学思. 三聚氰胺甲醛微球的制备及模板法构建聚谷氨酸基微胶囊. 高等学校化学学报, 2011, 32(10): 2447.

ZHANG Ying, YAN Shi-Feng, RAO Shui-Qin, ZHENG Yan-Zhen, YIN Jing-Bo*, CHEN Xue-Si*. Preparation of Melamine-formaldehyde Microspheres and Microcapsules Based on Poly(glutamic acid) by Template Method. Chem. J. Chinese Universities, 2011, 32(10): 2447.

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