高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

温度和pH双敏性PVME/CMCS水凝胶辐射交联制备及其性能

郁杨1, 尹静波1, 罗坤1, 谢勇涛1, 颜世峰1, 马嘉2, 陈学思2   

    1. 上海大学材料科学学院高分子材料系, 上海 201800;
    2. 中国科学院长春应用化学研究所高分子物理与化学国家重点实验室, 长春 130022
  • 收稿日期:2007-08-06 修回日期:1900-01-01 出版日期:2008-02-10 发布日期:2008-02-10
  • 通讯作者: 尹静波,陈学思

Preparation of Temperature- and pH-Sensitive PVME/CMCS Hydrogels via Electron Beam Irradiation Cross-linking and Their Properties

YU Yang1, YIN Jing-Bo1*, LUO Kun1, XIE Yong-Tao1, YAN Shi-Feng1, MA Jia2, CHEN Xue-Si2*   

    1. Department of Polymer Materials, College of Material Science, Shanghai University, Shanghai 201800, China;
    2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2007-08-06 Revised:1900-01-01 Online:2008-02-10 Published:2008-02-10
  • Contact: YIN Jing-Bo,CHEN Xue-Si

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被引次数

27

摘要： 以聚甲基乙烯基醚(PVME)和羧甲基壳聚糖(CMCS)为原料, 采用电子束辐照交联方法制备聚甲基乙烯基醚/羧甲基壳聚糖(PVME/CMCS)水凝胶, 研究了温度、pH值、CMCS含量等对PVME/CMCS水凝胶溶胀度的影响, 同时以5-氟尿嘧啶(5-Fu)作模型药物, 初步探讨了凝胶药物释放性能. 结果表明, 辐射剂量在20—40 kGy时, 凝胶分数随辐射剂量的增加而快速增加, 辐射40 kGy以后趋于平衡. 在相同辐射剂量下, 随着体系中CMCS含量的增加, 凝胶分数反而减少. 该水凝胶具有一定的温度和pH敏感性, 其低临界溶解温度(LCST)在35 ℃左右, 并且在相同时间内和25及37 ℃下的溶胀反复可逆, 表现出较快的响应性. pH<3.0和pH>5.0时, 溶胀度较大; pH值为3.0~5.0时, 凝胶网络由于静电力收缩, 溶胀度较小. CMCS含量的增加和辐射剂量的减小均可提高凝胶载药量. 药物释放时间可通过改变体系中CMCS的含量和辐射剂量来调节.

关键词: 敏感性, 水凝胶, 药物释放, 聚甲基乙烯基醚, 羧甲基壳聚糖

Abstract: Hydrogels based on poly(vinyl methyl ether) (PVME) and carboxymethylchitosan (CMCS) were prepared with electron beam irradiation(EB) cross-linking at room temperature. The effects of temperature, pH, CMCS content on the swelling properties of PVME/CMCS hydrogels were studied. The release behavior of a drug was tentatively investigated as well. The results show that the gel fraction of PVME/CMCS blend gels increases rapidly and then levels off above the radiation dose of 40 kGy, and it decreases with the increase of CMCS content in PVME/CMCS system. The hydrogels are thermo- and pH-sensitive, and show a fast swelling reversibility. At pH<3.0 and pH>5.0, the hydrogels have a higher swelling ratio; however, the swelling ratio is relatively lower in the pH range of 3.0—5.0 due to the electrostatic force. Increasing CMCS content and decreasing irradiation dose can improve the drug loading. The release of 5-fluorouracil can be governed by regulating the CMCS content and irradiation dose.

Key words: Sensitivity, Hydrogel, Drug release, Poly(vinyl methyl ether), Carboxymethylchitosan

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