快速响应大孔聚(N-异丙基丙烯酰胺-co-丙烯酸)水凝胶的合成及表征

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (12): 2370.

快速响应大孔聚(N-异丙基丙烯酰胺-co-丙烯酸)水凝胶的合成及表征

张建涛, 黄世文, 汪璐玲, 卓仁禧

武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室, 武汉430072

收稿日期:2003-10-27 出版日期:2004-12-24 发布日期:2004-12-24
基金资助:
国家重点基础研究发展规划项目(批准号:G1999064703);国家自然科学基金(批准号:20204009)资助

Preparation and Characterization of Fast-responsive Porous Poly(N-isopropylacrylamide-co-acrylic Acid) Hydrogels

ZHANG Jian-Tao, HUANG Shi-Wen, WANG Lu-Ling, ZHUO Ren-Xi

Key Laboratory of Biomedical Polymers, Ministry of Education; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 470072, China

Received:2003-10-27 Online:2004-12-24 Published:2004-12-24

摘要/Abstract

摘要： 以聚乙二醇6000为成孔剂,由自由基引发N-异丙基丙烯酰胺(NIPA)和丙烯酸(AAc)共聚交联得到大孔凝胶,研究了凝胶对环境温度的响应性能.在凝胶制备过程中,PEG6000分子充当成孔剂,得到的凝胶具有大孔结构.这种大孔结构有利于水分子的进出,大孔凝胶对温度变化有较快的响应速率.增加亲水单体AAc的含量,凝胶的LCST有所升高,凝胶的亲水性增强,在较低温度下凝胶的溶胀率也随之升高.振荡实验表明,所得的大孔凝胶具有反复使用的能力.

关键词: 温度敏感性, N-异丙基丙烯酰胺, 水凝胶, 大孔, 快速响应

Abstract: Temperature-sensitive porous poly(N-isopropylacrylamide-co-acrylic acid)[P(NIPA-co-AAc)] hydrogels with fast responsive properties were prepared by radical copolymerization in aqueous solution via using PEG6000 as the pore-forming agent. In comparison to the conventional gels, the porous P(NIPA-co-AAc) gels exhibited faster response rate to temperature changes and higher swelling ratios at the temperature below lower critical solution temperature(LCST), which can be attributed to the porous structure formed in the process of the polymerization/crosslinking. With increasing the contents of AAc in the gel matrixs, the LCST increased, which was caused by the high hydrophilicity of AAC component. The results suggest the potential of these novel porous hydrogels for the controlled release of drugs, especially for macromolecular drugs.

Key words: Temperature-sensitivity, N-Isopropylacrylamide, Hydrogel, Macropore, Fast responsivity

中图分类号:

O633

TrendMD:

张建涛, 黄世文, 汪璐玲, 卓仁禧. 快速响应大孔聚(N-异丙基丙烯酰胺-co-丙烯酸)水凝胶的合成及表征. 高等学校化学学报, 2004, 25(12): 2370.

ZHANG Jian-Tao, HUANG Shi-Wen, WANG Lu-Ling, ZHUO Ren-Xi . Preparation and Characterization of Fast-responsive Porous Poly(N-isopropylacrylamide-co-acrylic Acid) Hydrogels. Chem. J. Chinese Universities, 2004, 25(12): 2370.

参考文献

[1] 　Zhang X.Z.,Yang Y.Y.,W ang F.J.et al..L angm uir[J],2002,18:2013—2018 [2] 　Zhang J.T.,Cheng S.X.,H uang S.W.et al..M acromo .lR ap id.Com unn.[J],2003,24:447—451 [3] 　Shan tha K.L.,H arding D.R.K..In t.J.Pharm.[J],2000,207:65—704 [4] 　ZHAN G X ian-Zheng(张先正),ZHUO R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],2000,21(8):1309—1311 [5] 　ZHAN G X ian-Zheng(张先正),ZHUO R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],2000,21(11):1776—1778 [6] 　Sch ild H.G..P rog.Po lym.Sci.[J],1992,17:163—249 [7] 　H irokaw a Y.,T anaka T..J.Chem.Phys.[J],1984,81:6379—6380 [8] 　Zhang X.Z.,Zhuo R.X.,Cui J.Z.et al..In t.J.Pharm.[J],2002,235:43—50 [9] 　L iu F.,T ao G.L.,Zhuo R.X..Po lym.J.[J],1993,25:561—567 [10] 　Kurisaw a M.,Yokoyam a M.,O kano T..J.Con tro .lR e.l[J],2000,69:127—137 [11] 　Sh ibayam a M.,Ikk i F.,Inamo to S.et al..J.Chem.Phys.[J],1996,105:4358—4366 [12] 　M a C.S.,Zhang W.M.,C iszkow ska M..J.Phys.Chem.B[J],2001,105:10446—10452 [13] 　Zhang X.Z.,Zhuo R.X..Eur.Po lym.J.[J],2000,36:2301—2303 [14] 　Zhuo R.X.,L iW..J.Po lym.Sc.iPart A:Po lym.Chem.[J],2003,41:152—159 [15] 　Feil H.,Bae Y.H.,Feijen J.et al..M acromo lecules[J],1993,26:2496—2500 [16] 　Zhang J.T.,Cheng S.X.,Zhuo R.X..J.Po lym.Sc.iPart A:Po lym.Chem.[J],2003,41:2390—2392 [17] 　H iro se H.,Sh ibayam a M..M acromo lecules[J],1998,31:5336—5342 [18] 　M atsuo E.S.,T anaka T..J.Chem.Phys.[J],1988,89:1695—1703 [19] 　Sh ibayam a M.,N agai K..M acromo lecules[J],1999,32:7461—7468 [20] 　Zhang J.T.,Cheng S.X.,Zhuo R.X..Co llo id Po lym.Sc.i[J],2003,281:580—583 [21] 　Cheng S.X.,Zhang J.T.,Zhuo R.X..J.B iom ed.M ater.R es.[J],2003,67A:96—103