高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (11): 2051-2053.

• 研究简报 • 上一篇    下一篇

低价钛促进的1,2-二氢喹唑啉-4(3H)-酮的合成

史达清1,2,3, 荣良策1, 王菊仙1, 王香善1,2, 屠树江1,2, 胡宏纹3   

  1. 1. 徐州师范大学化学系, 徐州221116;
    2. 江苏省药用植物生物技术重点实验室, 徐州221116;
    3. 南京大学化学系, 南京210093
  • 收稿日期:2003-10-17 出版日期:2004-11-24 发布日期:2004-11-24
  • 基金资助:

    江苏省高等学校自然科学基金(批准号:03KJB150136)资助

Synthesis of 1,2-Dihydroquinazolin-4(3H)-ones Promoted by Low-valent Titanium

SHI Da-Qing1,2,3, RONG Liang-Ce1, WANG Ju-Xian1, WANG Xiang-Shan1,2, TU Shu-Jiang1,2, HU Hong-Wen3   

  1. 1. Department of Chemistry, Xuzhou Normal University, Xuzhou 221116, China;
    2. The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116, China;
    3. Department of Chemistry, Nanjing University, Nanjing 210093, China
  • Received:2003-10-17 Online:2004-11-24 Published:2004-11-24

关键词: 低价钛, 1, 2-二氢喹唑啉-4(3H)-酮, 合成

Abstract: Dihydroquinazolin-4(3H)-ones were synthesized by the reaction of o-nitrobenzamides with aromatic aldehydes or cyclones promoted by the low-valent titanium reagent(TiCl4-Zn system). The products were characterized by elementary analysis, IR, 1H NMR and X-ray single crystal diffraction. This method possesses the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.

Key words: Low-valent titanium, 1,2-Dihydroquinazolin-4(3H)-one, Synthesis

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