高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (10): 1860.

• 研究简报 • 上一篇    下一篇

超声波下2″,3″-二溴化三尖杉宁碱的高效还原研究

金晓英1, 李明1, 陈建民1, 陈家宽2, 杜迎翔3   

  1. 1. 复旦大学环境科学与工程系, 上海200433;
    2. 复旦大学生命科学学院生物多样性科学研究所、生物多样性与生态工程教育部重点实验室, 上海200433;
    3. 中国药科大学分析化学教研室, 南京210009
  • 收稿日期:2003-11-24 出版日期:2004-10-24 发布日期:2004-10-24
  • 基金资助:

    国家自然科学基金(批准号:20377008)资助

Highly Effective Reduction of 2″,3″-Dibromocephalomannine Under Ultrasound Irradiation

JIN Xiao-Ying1, LI Ming1, CHEN Jian-Min1, CHEN Jia-Kuan2, DU Ying-Xiang3   

  1. 1. Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;
    2. Key Laboratory for Biodiversity Science and Ecological Engineering of Ministry of Education, Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai 200433, China;
    3. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China
  • Received:2003-11-24 Online:2004-10-24 Published:2004-10-24

PDF (PC)

关键词: 2&Prime, 3&Prime, -二溴化三尖杉宁碱, 三尖杉宁碱, 超声波, 金属粉末, 还原

Abstract: Dibromocephalomannine(DIBROCs)is the intermediate product in the purification of taxol. In this paper, we successfully realized the efficient conversion of DIBROCs to cephalomannine under ultrasound irradiation for the first time. Ultrasound irradiation, a favorable acceleration of reaction rates, could solve the problems of incomplete conversion of DIBROCs to cephalomannine and the by-products due to long reaction time under the traditional stirring condition. The results showed that under ultrasound irradiation zinc powder was more effective than other metal powder and the proper reaction temperature was 20 ℃. Under this condition the conversion was more than 98% in 40 min.

Key words: Dibromocephalomannine, Cephalomannine, Ultrasound wave, Metal powder, Reduction

中图分类号: 

TrendMD: