高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (1): 68.

• 论文 • 上一篇    下一篇

七配位二聚体配合物{(PhCH2)2Sn·[2,6-(O2C)2C5H3N](CH3OH)}2的合成及结构

尹汉东1, 王传华1, 王勇1, 马春林1, 邵建新2   

  1. 1. 聊城大学化学系, 聊城 252059;
    2. 潍坊医学院生物化学教研室, 潍坊 261000
  • 收稿日期:2001-11-16 出版日期:2003-01-24 发布日期:2003-01-24
  • 通讯作者: 尹汉东(1956年出生),男,教授,主要从事金属有机合成.E-mail:handongyin@163.com E-mail:handongyin@163.com
  • 基金资助:

    教育部骨干教师基金;山东省自然科学基金(批准号:Y2000B08)资助

Synthesis and Structure of Seven-coordinate Dimer {(PhCH2)2Sn[2,6-(O2C)2C5H3N](CH3OH)}2

YIN Han-Dong1, WANG Chuan-Hua1, WANG Yong1, MA Chun-Lin1, SHAO Jian-Xin2   

  1. 1. Department of Chemistry, Liaocheng University, Liaocheng 252059, China;
    2. Department of Chemistry, Weifang Medical College, Weifang 261000, China
  • Received:2001-11-16 Online:2003-01-24 Published:2003-01-24

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摘要： 在三乙胺存在下利用三苄基氯化锡和2,6-吡啶二甲酸,以1:1摩尔比反应,合成了七配位二聚体{(PhCH2)2Sn[2,6-(O2C)2C5H3N](CH3OH)}2.通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征.用X射线单晶衍射法测定了该化合物的晶体结构.化合物为三斜晶系,P1空间群,晶胞参数a=0.9625(6)nm,b=1.0947(9)nm,c=1.996(3)nm,α=90.00(2)°,β=87.69(3)°,γ=90.00(3)°,Z=2,V=2.102(6)nm3,μ=1.248mm-1,F(000)=1000,R1=0.0476,wR2=0.0782.化合物中2个锡原子呈七配位畸变五角双锥构型.生物活性测试结果表明,该化合物具有较强的体外抗肿瘤活性.

关键词: 七配位有机锡配合物, 2, 6-吡啶二甲酸, 合成, 晶体结构

Abstract: A novel seven-coordinate dimer {(PhCH2)2Sn[2,6-(O2C)2C 5H3N](CH3OH)}2 was synthesized by the reaction of(PhCH2)3SnCl with 2,6-pyridine dicarboxylic acid in 1:1 molar ratio in methanol with Et3N. The structure of the dimmer was characterized by elemental analysis, IR, 1H NMR, and X-ray single crystal diffraction. The crystal belongs to a triclinic system with space group P1, a=0.962 5(6) nm, b=1.094 7(9) nm, c=1.996(3) nm, α=90.00(2)°, β=87.69(3)°, γ=90.00(3)°, Z=2, V=2.102(6) nm3, μ=1.248 mm-1, F(000)=1 000, R1=0.047 6, wR2= 0.078 2. In the crystals of complex, the tin atoms rendered seven-coordinate in a distorted pengonal bipyramidal structure. The complex was tested in vitro against human tumour cell lines, MCF-7 and WiDr, and displayed a higher activity.

Key words: Seven-coordinate organotin complex, 2,6-Pyridine dicarboxylic acid, Synthesis, Crystal structure

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