高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (9): 1660.

• 研究论文 • 上一篇    下一篇

新型有机-无机杂化材料(C3H5N2)4·PMoⅤMo11ⅥO40·4DMF·2H2O的合成、结构及抗前列腺癌活性研究

韩正波1, 常雅萍2, 栾国有1, 李娟2, 王恩波1   

  1. 1. 东北师范大学化学学院, 长春 130024;
    2. 吉林大学医学部, 长春 130021
  • 收稿日期:2001-06-08 出版日期:2002-09-24 发布日期:2002-09-24
  • 通讯作者: 王恩波(1937年出生),男,教授,博士生导师,从事多酸化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29471008)资助

Synthesis, Crystal Structure and Anti-prostate Cancer Activity of a Novel Organic-inorganic Hybrid Material:(C3H5N2)4PMoⅤMo11ⅥO40·4DMF·2H2O

HAN Zheng-Bo1, CHANG Ya-Ping2, LUAN Guo-You1, LI Juan2, WANG En-Bo1   

  1. 1. Department of Chemistry, Northeast Normal University, Changchun 130024, China;
    2. Medical department, Jilin University, Changchun 130021, China
  • Received:2001-06-08 Online:2002-09-24 Published:2002-09-24

PDF (PC)

摘要： 制备了有机-无机杂化材料(C3H5N2)4·PMoⅤMo11ⅥO40·4DMF·2H2O.用元素分析、红外光谱和X射线衍射对其进行了表征,该晶体属三斜晶系,P1空间群,晶胞参数为a=1.2423(3)nm,b=1.2666(3)nm,c=1.3341(3)nm,V=1.7423(6)nm3,α=70.56(3)°,β=71.16(3)°,γ=64.18(3)°,Z=1,R1=0.0585,wR2=0.1885.结构解析表明,十二钼磷酸阴离子和质子化的咪唑分子通过静电引力和氢键相互作用.采用MTT法,对其体外抗前列腺癌活性及毒性进行了研究.

关键词: 有机-无机杂化材料, 多金属氧酸盐, 咪唑, 晶体结构, 抗前列腺癌活性

Abstract: Anew compound, (C3H5N2)4PMoⅤMo11ⅥO40)·4C3H7NO·2H2O, was synthesized and structurally characterized by elemental analysis, ESRspectra and X-ray diffraction. This is the first example of imidazole-polyoxometalate species to our knowledge. It crystallized in a triclinic space group, P1 with a=1.2423(3) nm, b=1.2666(3) nm, c=1.3341(3) nm, V=1.7423(6) nm3, α=70.56(3)°, β=71.16(3)°, γ=64.18(3)°, Z=1, R=0.0585, wR=0.1885. X-ray crystallographic study showed that the crystal structure was constructed by electrostatic attractions and hydrogen bonds between a dodecamolybdophosphoric anion and an imidazole. Anti-prostate cancer(PC-3m) activities of the title compound are also reported.

Key words: Organic-inorganic hybrid material, Polyoxometalate, Imidazole, Crystal structure, Anti-prostate cancer activities

中图分类号: 

TrendMD: