高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (8): 1598.

• 研究简报 • 上一篇    下一篇

水溶性C60-β丙氨酸衍生物清除超氧阴离子自由基O2-·及对小鼠胸腺细胞生长影响的研究

孙涛1, 金亚旭1, 陈万喜1, 张欣欣2, 陈卫祥1, 徐铸德1   

  1. 1. 浙江大学化学系;
    2. 生物系, 杭州 310027
  • 收稿日期:2001-01-04 出版日期:2002-08-24 发布日期:2002-08-24
  • 作者简介:徐铸德(1944年出生),男,教授,博士生导师,从事化学动力学和功能分子材料研究.
  • 基金资助:

    国家教育部博士学科点基金(批准号:97033510)资助

Studies on Superoxide Radical Scavenging Activity of Water-soluble β-Alanine C60 Adducts and It′s Effect on the Growth of Mouse Thymus Cell

SUN Tao1, JIN Ya-Xu1, CHEN Wan-Xi1, ZHANG Xin-Xin2, CHEN Wei-Xiang1, XU Zhu-De1   

  1. 1. Department of Chemistry;
    2. Department of Biology, Zhejiang University, Hangzhou 310027, China
  • Received:2001-01-04 Online:2002-08-24 Published:2002-08-24

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关键词: C60-&beta, 丙氨酸衍生物, 超氧阴离子自由基O2-·, , 邻苯三酚自氧化, 噻唑蓝(MTT)法

Abstract: The ability of water soluble β-alanine C60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto-oxidation method. It is found that β-alanine C60 adducts have an excellent efficiency in eliminating superoxide radical generated from auto oxidation of pyrogallol. At a mass concentration level of 150 μg/mLfor β-alanine C60 adducts, the radical scavenging efficiency is approximately equivalent to one enzyme unit, in vitro experiments show that β-alanine C60 adducts can enhance the activity of mouse thymus cells and prolong their life time span. It reveals the potential use of these β-alanine C60 adducts as the novel potent free radical scavengers in biological systems.

Key words: β-Alanine C60 adducts, Superoxide radical, Auto-oxidation of pyrogallol, Thiazolyl blue

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