高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (11): 2102.

• 研究论文 • 上一篇    下一篇

1,5-苯并硫氮杂-α-氨基-β-内酰胺衍生物的合成及立体结构(Ⅱ)

张萍, 郝振芳, 李媛   

  1. 河北师范大学化学系, 石家庄050016
  • 收稿日期:2001-09-11 出版日期:2002-11-24 发布日期:2002-11-24
  • 通讯作者: 李　媛(1957年出生),女,硕士,教授,从事有机化学研究.E-mail:Yuanli@mai.lhebtu.edu.cn E-mail:Yuanli@mai.lhebtu.edu.cn
  • 基金资助:

    河北省自然科学基金(批准号:200154)资助

Synthesis and Steric Structure of α-Amino-β-lactam Derivatives of 1,5-Benzothiazepines

ZHANG Ping, HAO Zhen-Fang, LI Yuan   

  1. Department of Chemistry, Hebei Normal University, Shijiazhuang 050016, China
  • Received:2001-09-11 Online:2002-11-24 Published:2002-11-24

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摘要： 用一种甘氨酸N-端保护试剂和1,5-苯并硫氮杂反应,合成了5个1,5-苯并硫氮杂-α-氨基-β-内酰胺衍生物,其结构经元素分析、1

关键词: 1, 5-苯并硫氮杂, &beta, -内酰胺, 丁二酰亚胺乙酰氯, 合成

Abstract: Benzothiazepines reacted with a new N-protected agent of glycine to give the title compounds. The configuration and conformation of the products were determined by X-ray crystal analysis. The results also revealed that the reaction was stereospecific. The two substituents at β-lactam were on the same side, the seven-membered ring was in chair-like conformation.

Key words: Benzothiazepine, β-Lactam, N-[(Chloroformyl)methyl]succimide, Synthesis

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