高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (11): 2073.

• 研究简报 • 上一篇    下一篇

萘普生分子印迹拆分及亲和吸附平衡常数的测定

雷建都, 谭天伟   

  1. 北京化工大学生物化工系, 北京100029
  • 收稿日期:2001-07-02 出版日期:2002-11-24 发布日期:2002-11-24
  • 通讯作者: 谭天伟(1964年出生),男,博士,教授,博士生导师,从事生化分离、酶工程和发酵工程领域的研究.
  • 基金资助:

    国家自然科学基金(批准号:29976004);教育部优秀青年教师奖励基金资助

Chiral Separation on Naproxen and Determination of Chromatography Equilibrium Constant Using Molecular Imprinting

LEI Jian-Du, TAN Tian-Wei   

  1. Department of Biochemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2001-07-02 Online:2002-11-24 Published:2002-11-24

关键词: 分子印迹聚合物, 拆分, 萘普生, 亲和吸附

Abstract: A chiral stationary phase for naproxen separation was prepared by means of molecular imprinting, in which acrylamide and ethylene glycol dimethacrylate were copolymerized in the presence of template. Racemic naproxen was efficiently resolved on the molecular imprinting polymer. The concentration of acetic acid in the mobile phase was optimized. A new affinity chromatography model using molecular imprinting was established by which the agreement between the simulated and experimental results was obtained. The results suggested that affinity chromatography mechanism controled the retention in this system.

Key words: Molecular imprinting polymer, Chiral separation, Naproxen, Affinity adsorption

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