高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (1): 53.

• 研究论文 • 上一篇    下一篇

3-芳基-6-(6-/8-取代-4-氯喹啉-3-基)1,2,4-三唑-[3,4-b]-1,3,4-噻二唑类化合物的合成

乔仁忠1, 惠新平1, 张自义1, 程东亮1, 刘锦熙2   

  1. 1. 兰州大学化学化工学院, 应用有机国家重点实验室, 兰州 730000;
    2. 兰州医学院化学教研室, 兰州 730000
  • 收稿日期:2000-10-18 出版日期:2002-01-24 发布日期:2002-01-24
  • 通讯作者: 张自义(1933年出生),男,教授,博士生导师,从事杂环及杂原子化合物研究.

Synthesis of 3-Aryl-6-(6-/8-substituted-4-chloroquinoline-3-yl)-s- triazolo-1,3,4-thiadiazoles

QIAO Ren-Zhong1, HUI Xin-Ping1, ZHANG Zi-Yi1, CHENG Dong-Liang1   

  1. 1. College of Chemistry and Chemical Engineering, National Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, China;
    2. Department of Chemistry, Lanzhou Medical College, Lanzhou 730000, China
  • Received:2000-10-18 Online:2002-01-24 Published:2002-01-24

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摘要： 研究了3-芳基-4-氨基-5-巯基-1,2,4-三唑与6-/8-取代-4-羟基喹啉-3-羧酸在三氯氧磷催化下的反应,制得16个新的3-芳基-6-(6-/8-取代-4-氯喹啉-3-基)-1,2,4-三唑[3,4-b]-1,3,4-噻二唑.新化合物的结构通过元素分析、IR、1H NMR和MS确定,讨论了其波谱性质.

关键词: 1, 2, 4-三唑[3, 4-b]-1, 3, 4-噻二唑, 合成, 波谱性质

Abstract: Condensation of 4-amino-3-aryl-5-mercap to-1,2,4-triazole with 6-/8-substiuted-4-chloro|quinoline-3 carboxylic acid in the presence of phosphorus oxychloride gave 16 novel 3-aryl-6-(6-/8-substituted-4-chloroquinoline-3-yl)-s-triazolo-1,3,4-thiadiazoles(3a_3p). Their structures were determined by elementary analyses, IR, 1H NMR and MS spectra. Their spectral properties were also discussed.

Key words: 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole, Synthesis, Spectral properties

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