高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (S1): 59.

• 研究论文 • 上一篇    下一篇

铝的毒性作用对铁、钙和镁生理功能的影响及相关机理的研究概况

章福平, 毕树平, 干宁, 刘剑, 杨立   

  1. 南京大学化学系, 南京 210093
  • 收稿日期:2001-07-31 出版日期:2001-12-31 发布日期:2001-12-31
  • 通讯作者: 毕树平(1961年生),男,教授,主要从事坏境分析化学和电分析化学研究.
  • 基金资助:

    国家自然科学基金No.20075010资助课题.

A Review of the Toxic Effects of Al on the Biological Functions of Fe, Ca and Mg and Related Toxic Mechanisms

ZHANG Fu-Ping, BI Shu-Ping, GAN Ning, LIU Jian, YANG Li   

  1. Department of Chemistry, Nanjing University, Nanjing, 210093, China
  • Received:2001-07-31 Online:2001-12-31 Published:2001-12-31

PDF (PC)

被引次数

1

摘要：

本文综述了近年来铝的毒性作用对铁、钙和镁生理功能的影响及相关机理的研究概况.并讨论了铝在阿尔茨海默氏病(Alzhmers disease, AD),帕金森氏病(Parkinson's disease, PD)及透析病中毒性作用机理.引用文献50篇.

关键词: 铝, 铁, 钙, 镁, 综述

Abstract:

Aluminum (Al) is not an essential element for human body. On the contrary, Fe,Ca, and Mg are required to mediate many normal metabolisms. However, because of the resemblance of both ionic diameters and ionic charges between Al and Fe, Ca, and Mg,Al expects to disturb the biological activities of its analogues. In this paper, the recent progresses of the studies of the toxic effects of Al on the biological functions of Fe, Ca and Mg have been reviewed. The corresponding mechanisms of the toxicogenic action of Al in these cases are also discussed. A typical toxicity of Al is resulted from its promotion of the ability of Fe to produce free radical or reactive oxidants that will lead to 'oxidative stress',one of the factors of the pathology of Alzhmers disease and Parkinson's disease. The substitutions of Fe and Ca for Al in some biological functional components will result in anemia and osteopathia respectively as well. In addition, fifty references have been cited.

Key words: Aluminum, Iron, Calcium, Magnesium, Review

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