高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (2): 317.

• 研究论文 • 上一篇    下一篇

细胞相容性聚氨酯的合成及其细胞相容性研究

管建均1, 高长有1, 沈家骢1,2   

  1. 1. 浙江大学高分子科学与工程系, 杭州 310027;
    2. 吉林大学化学系, 长春 130023
  • 收稿日期:1999-10-10 出版日期:2001-02-24 发布日期:2001-02-24
  • 通讯作者: 高长有(1966年出生),男,博士,副教授,主要从事组织工程材料研究.
  • 基金资助:

    国家自然科学基金(批准号:59803006);国家重点基础研究发展规化项目(批准号:G1999054305)资助

Preparation and Characterization of Cell Compatible Polyurethane

GUAN Jian-Jun1, GAO Chang-You1, SHEN Jia-Cong1,2   

  1. 1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China;
    2. Department of Chemistry, Jilin University, Changchun 130023, China
  • Received:1999-10-10 Online:2001-02-24 Published:2001-02-24

PDF (PC)

被引次数

32

摘要： 在紫外光和过氧化氢的共同作用下,过氧化氢基团被引人到聚氨酯膜(PU)表面.将丙烯酸羟乙酯(HEA)吸附于氧化后的PU膜表面,在紫外光下实现了膜表面的接枝,并考察了接枝膜的表面性能.人体脐带静脉内皮细胞粘附和生长的研究表明,HEA接枝后的PU表面细胞粘附率显著提高,细胞的生长速率加快,增值率提高.

关键词: 聚氨酯, 接枝聚合, 丙烯酸羟乙酯, 内皮细胞, 细胞相容性

Abstract: Cell compatible polyurethane(PU) was obtained by surface photo-grafting of 2-hydroxyethyl acrylate(HEA) onto PUmembrane surface. Hydroperoxide groups were introduced onto PUmembrane surface by photo-oxidization, then the oxidized membrane, immersed previously in monomer solution, was irradiated under UVlight. The grafted copolymers were characterized by ATR-FTIRspectra, element spectroscopy for chemical analysis(ESCA) and static water contact angle. The results showed that grafting was confined within the surface layer. Cell compatible study revealed that the attachment and growth of human umbilical vein endothelial(HUVE) cells were improved after HEAgrafting. Cells grew faster on the surface with higher oxygen content.

Key words: Polyurethane, Grafting polymerization, 2-Hydroxyethyl acrylate, Human umbilical vein endothelial cell, Cell compatibility

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