高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (4): 513.

• 论文 • 上一篇    下一篇

二氯二乙基锡与DNA作用的研究

李青山1, 刘锐铃1, 黄计军1, 杨频2   

  1. 1. 山西医科大学药学院, 太原 030001;
    2. 山西大学分子科学研究所, 太原 030006
  • 收稿日期:1999-08-30 出版日期:2000-04-24 发布日期:2000-04-24
  • 通讯作者: 李青山(1965年出生),男,博士,教授,主要从事生物无机化学和药物化学研究.
  • 基金资助:

    国家科技部(批准号:96-901-06-038);国家自然科学基金(批准号:39900185);山西省科委重点资助项目(批准号:961036

Studies on the Interaction of Et2SnCl2 with DNA

LI Qing-Shan1, LIU Rui-Ling1, HUANG Ji-Jun1, YANG Pin2   

  1. 1. College of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;
    2. Institute of Molecule Science, Shanxi University, Taiyuan 030006, China
  • Received:1999-08-30 Online:2000-04-24 Published:2000-04-24

摘要: 利用循环伏安、紫外光谱和粘度测定等手段,对二氯二乙基锡[Et2SnCl2]与DNA的作用机制进行了研究.结果明,Et2SnCl2主要作用于DNA的骨架磷酸基团,使DNA构象收缩,相对粘度增加,产生减色效应,始终未观察到增色效应.提出了Et2SnCl2对DNA可能的作用机制模型.

关键词: 抗肿瘤, 二氯二乙基锡, DNA

Abstract: In this paper, the spectrophotometric, cyclic voltammetric methods and viscosity determination were used to study the interaction of the anti tumor active Et2SnCl2 with DNA. The results indicate that Et2SnCl2 mainly reacts electrostatically with the phosphate backbone of DNA, leading to an increase of the relative viscosity of DNAand the occurring of hypochromism of DNA. No hyperchromism was observed during the whole reaction process. The molecular action mechanism of Et2SnCl2 with DNAwas proposed.

Key words: Antitumor, Et2SnCl2, DNA

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