高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (7): 1415-1425.doi: 10.7503/cjcu20200251

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

框架核酸辅助的仿生膜构建

严磊,毛秀海*(),左小磊*()   

  1. 上海交通大学医学院附属仁济医院分子医学研究院, 上海市核酸化学与纳米医学重点实验室, 上海 200127
  • 收稿日期:2020-05-06 出版日期:2020-07-10 发布日期:2020-06-17
  • 通讯作者: 毛秀海,左小磊 E-mail:xhmaosinap@163.com;zuoxiaolei@sjtu.edu.cn
  • 基金资助:
    国家自然科学基金(21804088);上海交通大学医学院高水平地方高校创新团队(SSMU-ZLXX20180701);上海交通大学医学院高峰学科-“临床专职科研队伍”(20171913);上海市教育发展基金会和教育委员会“曙光计划”(18SG16)

Biomimicry of Cellular Membrane with Framework Nucleic Acids

YAN Lei,MAO Xiuhai*(),ZUO Xiaolei*()   

  1. Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Received:2020-05-06 Online:2020-07-10 Published:2020-06-17
  • Contact: MAO Xiuhai,ZUO Xiaolei E-mail:xhmaosinap@163.com;zuoxiaolei@sjtu.edu.cn
  • Supported by:
    † National Natural Science Foundation of China(21804088);Innovative Research Team of High-level Local Universities in Shanghai, China(SSMU-ZLXX20180701);Shanghai Municipal Education Commission Gaofeng Clinical Medicine, China(20171913);“Shuguang Program” Supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission, China(18SG16)

摘要:

仿生膜的构建有利于了解并掌握生物膜的功能及其机理, 同时对其在生命医学及疾病诊断等相关领域的应用具有重要意义. 以框架核酸为组装单元, 构建新型仿生膜材料是一种有效且具有发展前景的方法和研究方向. 本文综述了框架核酸的设计、 制备与表征, 总结了框架核酸修饰到脂质膜上的方式. 同时, 对框架核酸辅助的仿生膜的应用情况进行了阐述, 并探讨了框架核酸在仿生膜研究领域所面临的机遇与挑战.

关键词: 生物仿生, 细胞膜, 框架核酸, DNA纳米技术

Abstract:

Biomimicry of cellular membrane is crucial for the study of cellular communications and transportation, and holds great potentials in various applications, including nanomedicine, nanopore based single molecule detection, cell imaging, drug delivery and cancer therapy. Owing to its ability to nanoscale precisely shape and manipulation, construction of framework nuclei acids(FNAs) provides a promising approach to bio-mimicking cellular membrane proteins and exploiting their functions and applications. In this review, we introduce the structure and imaging technology for FNAs as well as assembling methods for FNAs based artificial cellular membrane in recent years. In addition, the application fields as well as the existing opportunities and challenges of FNAs based biomimicry of cellular membrane are discussed.

Key words: Biomimicry, Cellular membrane, Framework nucleic acid, DNA nanotechnology

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