高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (8): 1210.

• 综合评述 • 上一篇    下一篇

DNA与其靶向分子相互作用研究进展

张蓉颖, 庞代文, 蔡汝秀   

  1. 武汉大学化学学院, 武汉 430072
  • 收稿日期:1998-12-04 出版日期:1999-08-24 发布日期:1999-08-24
  • 通讯作者: 庞代文
  • 作者简介:张蓉颖,女,23岁,博士研究生.
  • 基金资助:

    国家自然科学基金(批准号:29773034;39770220;39370213);教育部留学回国人员科研基金;湖北省自然科学基金(批

Interactions Between DNA and DNA-Targeting Molecules

ZHANG Rong-Ying, PANG Dai-Wen, CAI Ru-Xiu   

  1. Department of Chemistry, Wuhan University, Wuhan 430072, China
  • Received:1998-12-04 Online:1999-08-24 Published:1999-08-24

摘要: DNA与其靶向分子相互作用的研究不仅对阐述一些抗肿瘤、抗病毒药物及致癌物的作用机理,而且对进一步指导人工核酸酶的合成及DNA高级结构研究等方面的工作都具有重要意义.本文着重评述了近年来不同结构类型的DNA靶向分子与DNA相互作用研究方面的进展.

关键词: DNA, DNA靶向分子, 相互作用, 抗生素

Abstract: Studies on interactions between DNAand DNA-targeting molecules are of great importance not only to elucidating the action mechanisms of some anti-tumor and anti-viral drugs and some carcinogens, but also to the design of artificial nucleases and probes for DNA structures. In this article, recent advances in the studies of interactions between DNA and DNA-targeting molecules with different structures are reviewed.

Key words: DNA, DNA-targeting molecule, Interaction, Antibiotics

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