高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (9): 1416.

• 论文 • 上一篇    下一篇

5-氟脲嘧啶的D-氨基葡萄糖衍生物的合成及其抗肿瘤活性的研究

罗宣干, 卓仁禧, 李满庆   

  1. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1995-10-24 出版日期:1996-09-24 发布日期:1996-09-24
  • 通讯作者: 罗宣干,男,51岁,副教授.
  • 作者简介:罗宣干,男,51岁,副教授.
  • 基金资助:

    国家自然科学基金

Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Aminoglucose Residue

LUO Xuan-Gan, ZHUO Ren-Xi, LI Man-Qing   

  1. Department of Chemistry Wuhan University, Wuhan, 430072
  • Received:1995-10-24 Online:1996-09-24 Published:1996-09-24

摘要: 以α-氨基酸为连接基,将5-氟脲嘧啶同D-氨基葡萄糖键连合成了4种新的5-氟脲嘧啶的衍生物,并确认了它们的结构。体外抗肿瘤活性实验结果表明:链连的D-氨基葡萄糖使5-氟脲嘧啶的抗肿瘤活性有明显的提高,表明它们之间可能存在着某种抗肿瘤的协同作用。

关键词: D-氨基葡萄糖, 5-氟脲嘧啶, 抗肿瘤活性, &alpha, -氨基酸, 甲壳素

Abstract: This investigation describes the effect of D-aminoglucose on the antitumor activity of 5-fluorouracil.By choosing α-amino acids as connective group, we have synthesized 4 kinds of 5-fluorouracil derivatives containing D-aminoglucose residue.Their structures were confirmed by 1H NMR,IR, UVspectra and elemental analysis.The data of activity against the isolated ehrlich ascites tumor cells in vitro has been evaluated.The preliminary results show that these compounds all exhibit much better antitumor activity than 5-fluorouracil it-self does.

Key words: D-Aminoglucose, 5-Fluorouracil, Antitumor, α-Amino acid, Chitin

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