高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (9): 1476.

• 论文 • 上一篇    下一篇

Gd-DTPA氨基酸、短肽衍生物的合成及其磁共振成像造影性能的研究

罗毅1, 卓仁禧2, 范昌烈2   

  1. 1. 北京大学化学与分子工医学院, 北京, 100871;
    2. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1994-09-20 修回日期:1995-01-04 出版日期:1995-09-24 发布日期:1995-09-24
  • 通讯作者: 卓仁禧
  • 作者简介:罗毅,男,24岁,博士.
  • 基金资助:

    国家863计划项目资助

Studies on the Synthesis and Relaxivity of Amino Acids and Oligopeptides of Gd-DTPA Derivatives

LUO Yi1, ZHUO Ren-Xi2, FAN Chang-Lie2   

  1. 1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871;
    2. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1994-09-20 Revised:1995-01-04 Online:1995-09-24 Published:1995-09-24

PDF (PC)

被引次数

14

摘要： 合成了一系列二乙三胺五乙酸(DTPA)的疏水性氨基酸、短肽衍生物的Gd(Ⅲ)螯合物,研究了其磁共振成像造影性能。结果表明:螯合物的急性毒性与Gd-DTPA相当,自旋-晶格弛豫性能R1比Gd-DTPA略高。Gd-DTPA,氨基酸,短肽,急性毒性,自旋-晶格弛豫性能

关键词: Gd-DTPA, 氨基酸, 短肤, 急性毒性, 自旋一晶格弛豫性能

Abstract: The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems. Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting, Gd-DTPA is the first MRI contrast agent clinically used, the chelates of Gd(Ⅲ) and DTPA derivatives were more selective and less toxic than Gd-DTPA. In this paper,a series of amino acids and oligopeptides of Gd-DTPAderivatives were synthesized, The structures of these chelates were confirmed by IR and elementary analysis. Toxicity of chelate was almost the same as Gd-DTPA.The spin-lattice relaxivity (R1) of these chelates was a little bit larger than that of Gd-DTPA.

Key words: Gd(Ⅲ)-DTPA, Amino acid, Oligopeptide, Toxicity, Spin-lattice relaxivity

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