高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (11): 1740.

• 论文 • 上一篇    下一篇

1-(取代异噁唑基)-1,2,4-三唑和1-(取代嘧啶基)-1,2,4-三唑的合成及生物活性

黄震年, 李正名   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1994-11-26 修回日期:1995-07-29 出版日期:1995-11-24 发布日期:1995-11-24
  • 通讯作者: 李正名
  • 作者简介:黄震年,男,30岁,博士研究生
  • 基金资助:

    国家自然科学基金

Syntheses and Biological Activityies of 1-(Substituted Isoxazolyl)-1,2,4-triazoles and 1-(Substituted Pyrimidinyl)-1,2,4-triazoles

HUANG Zhen-Nian, LI Zheng-Ming   

  1. Elemento-Organic Chemistry Institute, Nankai Univcrsity, Tianjin, 300071
  • Received:1994-11-26 Revised:1995-07-29 Online:1995-11-24 Published:1995-11-24

摘要: 合成了15个新的1-(取代异噁唑基)-1,2,4-三唑和1-(取代嘧啶基)-1,2,4-三唑化合物,经元素分析、IR、1HNMR和MS证实其结构,并对其代表化合物进行了抑菌及植物生长调节活性的初步观察

关键词: 合成, 1-(取代异噁唑-1, 2, 4-三唑, 1-(取代嘧啶基)-1, 生物活性

Abstract: α-Oxo-α-(1,2,4-triazol-1-yl)ketene dithioacetals 1 reacted with hydroxylamine hydrochloride in the presence of barium hydrate in refluxing ethanol to give a mixture of isomeric 1-[5-alkylthioisoxazolyl)-1,2,4-triazoles 2 and 1-(3-alkylthioisoxazolyl)-1,2,4-triazoles 2'].Their mass spectral fragmentation was discussed respectively. On treatment with guanidine and thiourea in a refluxing sodium ethoxide, 1 afforded 1-(substitutedpyrimidinyl)-1,2, 4-triazoles 3 and 4. The preliminary biological tests show that isoxazolyltriazoles 2 and 2' have plant-regulatory activities.

Key words: Synthesis, 1-(Substituted isoxazolyl)triazoles, Pyrimidinyl triazoles, Biological activity

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