高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (4): 517.

• 研究论文 • 上一篇    下一篇

4H-1,2,4-三唑-4-基酮和醇的合成及其生物活性

廖联安1, 陈明德2, 张洪奎2, 郭奇珍2   

  1. 1. 厦门大学化学系, 厦门 361005;
    2. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室
  • 收稿日期:1992-07-05 修回日期:1992-12-02 出版日期:1993-04-24 发布日期:1993-04-24
  • 通讯作者: 廖联安

Syntheses and Bioactivities of 4H-1,2,4-triazol-4-yl Ketones and Alcohols

LIAO Lian-An1, CHEN Ming-De2, ZHANG Hong-Kui2, GUO Qi-Zhen2   

  1. 1. Deft, of Chem., Xiamen Univ., Xiamen, 361005;
    2. National Key Lab.of Elemento-Org.Chem., Nankai Univ.
  • Received:1992-07-05 Revised:1992-12-02 Online:1993-04-24 Published:1993-04-24

摘要: 1-(4H-1,2,4-三唑-4-基)频哪酮(2)与卤代烃在相转移催化条件下反应,得到具有较高产率的4H-1,2,4-三唑-4-基酮(3);进一步用硼氢化钾还原,得到近乎定量产率的醇(4)。初步的生物活性测定表明3和4有一定的延缓植物生长的作用和杀菌活性。

关键词: 1-(4H-1, 2, 4-三唑-4-基)频哪酮, 烷基化, 还原, 生物活性测定

Abstract: 1-(4H-1,2,4-Triazol-4-yl)pinacolone reacted with alkyl halide for 4 h under the condition of phase transfer catalysis to give 4H-1,2, 4-triazol-4-yl ketones (3) with the yields of 20%-93%.(3) were reduced by KBH4 to afford the corresponding alcohols (4) with the yields of 92%-95%.The preliminary results of bioassay show that (3) and (4) have lower plant growth retarding and fungicidal activities than those of paclobutrazol.

Key words: 1-(4H-1,2,4-Triazol-4-yl)pinacolone, Alkylation, Reduction, Bioassay

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