高等学校化学学报

高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (4): 425.

• 研究简报 • 上一篇    下一篇

1,2,4-三嗪类化合物的研究(ⅪⅤ)—3-甲氧基-5-甲基-6-乙酰-1,2,4-三嗪的合成及其与芳香醛的反应

程铁明, 雷光清, 王来新, 王动, 蔡孟深   

  1. 北京医科大学药学院
  • 收稿日期:1988-12-12 出版日期:1990-04-24 发布日期:1990-04-24
  • 通讯作者: 蔡孟深
  • 基金资助:

    国家自然科学基金

Chemistry of 1,2,4-Triazines(XIV)—Synthesis of 3-Methoxy-5-Methyl-6-Acetyl-1,2,4-Triazine and Its Condensation with Aromatic Aldehydes

Cheng Tieming, Lei Guangqing, Wang Laixin, Wang Dong, Cai Mengshen   

  1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing
  • Received:1988-12-12 Online:1990-04-24 Published:1990-04-24

PDF (PC)

摘要： 5或6-取代芳乙烯基-1,2,4-三嗪类化合物具有广谱抑菌活性[1.2],本文将3-甲氧基-5-甲基-6-乙酰-1,2,4-三嗪(Ⅱ)在HCI/AcOH体系中与芳香醛进行缩合反应,分别得到3-甲氧基-5-甲基-4′-羟基-肉桂酰基-1,2,4-三嗉(Ⅲ)和3-甲氧基-6-乙酰-5-[2-取代芳基-乙烯基]-1,2,4-三嗪(Ⅳ)。

关键词: 1, 2, 4-三嗪类化合物, 缩合反应, 13C NMR

Abstract: 3-Methoxy-5-methyl-6-acetyl- 1, 2, 4-triazine ( Ⅱ ) was synthesized and condensed with aromatic aldehydes to give 3-methoxy-5-methy]-6-(4-hydroxy)-cinnamy)-] ,2. 4-triazine( Ⅲ ) or 3-methoxy-6-acetyl-5-(2-aryl)-vinyl- 1, 2, 4-triazines ( Ⅳ ). The structure of these products were proved by IR, UV, MS, 1Hand 13C NMRspectra.

Key words: 1,2,4-Triazines, Condensation reaction, 13C NMR

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