高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (10): 1067.

• 研究论文 • 上一篇    下一篇

碳糊电极吸附/萃取伏安法测定氯氮平

彭图治, 杨忠萍, 吕荣山   

  1. 杭州大学化学系
  • 收稿日期:1989-06-21 出版日期:1990-10-24 发布日期:1990-10-24
  • 通讯作者: 彭图治, 邮编: 310028

Adsorptive/Extractive Voltammctry for Determining Clozapine at Carbon Paste Electrodes

Peng Tuzhi, Yang Zhongping, Lü Rongshan   

  1. Department of Chemistry, Hongzhou Univcersity, Hangzhou
  • Received:1989-06-21 Online:1990-10-24 Published:1990-10-24

摘要: 本文提出了测定抗精神病新药氯氮平的碳糊电极开路富集/介质交换/溶出伏安法模式,该药物在0.45V附近显示了氧化溶出峰,在1×10-6~1×10-8g/mL范围内峰电流与浓度成线性关系,检测限为4×10-9g/mL,比紫外光度法提高约100倍。研究表明,碳糊电极对该药物具有强烈的萃取和吸附作用,并且萃取在富集过程中起着主要的作用。该法具有很强的抗干扰能力,可以直接测定片剂和尿样中的药物含量。

关键词: 氯氮平, 吸附, 萃取, 溶出伏安法, 计时库仑法

Abstract: This paper reports differential pulse stripping voltammetry for determining clozapine, an an-tipsychotic drug, at carbon paste electrodes. Clozapine exhibits an anodic peak at 0. 45 V (vs Ag-AgCl). The response is linear at the range of 1× 10-6-1× 10-8g/mLwith a detection limit of 4×10-9 g/mL. It is demonstrated that the adsorption and extraction play an important role during preconcentration. The ratio of these two parts is evaluated by chronocoulpmetry. The open circuit accumulation/medium exchange/ stripping voltammetry scheme is used to measure clozapine in tablets and urine sample without pretreatment.

Key words: Clozapine, Adsorption, Extraction, Stripping voltammetry, Chronocoulometry

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