Abstract: As an emerging type of two-dimensional material, MXene has become a research focus because of its unique advantages including hydrophilicity, excellent mechanical properties, abundant surface functional groups, high conductivity, photothermal and photoelectric effects. As a result, it has been widely used in electromagnetic shielding, electrochemical energy storage, biomedicine, separation, sensor and seawater desalination. Although MXene has these excellent properties, its drawbacks such as poor compatibility with hydrophobic polymers, the impediment of electrolyte transport by negative charged functional groups and the ease of oxidation, all limit its practical application. Recently, efforts have been made by interface modification of MXene to solve its inherent defects. Subsequently, targeted structural design of MXene is carried out to improve the interface stability and further enhance its performance. In this paper, the research progress of interface modification and structure design of MXene composites is summarized, in which the structure and properties of MXene, the interface modification methods of MXene and the structure strategies of MXene composite are discussed followed by a brief prospect of MXene composite materials.