高等学校化学学报 ›› 2016, Vol. 37 ›› Issue (4): 648-653.doi: 10.7503/cjcu20150701

• 分析化学 • 上一篇    下一篇

微流控液液萃取-液液波导集成化分析系统

姜健1,2, 李盼盼2, 马滢雪2, 杨春光2, 徐章润2()   

  1. 1. 辽东学院化学工程学院, 丹东 118003
    2. 东北大学分析科学研究中心, 沈阳 110819
  • 收稿日期:2015-09-08 出版日期:2016-04-10 发布日期:2016-03-09
  • 基金资助:
    国家自然科学基金(批准号: 20975019, 21375012, 21305010)资助

Microfluidic Analysis System Integrated with Liquid-liquid Extraction and Liquid-liquid Waveguide

JIANG Jian1,2, LI Panpan2, MA Yingxue2, YANG Chunguang2, XU Zhangrun2,*()   

  1. 1. Institute of Chemical Engineering, Eastern Liaoning University, Dandong 118003, China
    2. Research Centre for Analytical Sciences, Northeastern University, Shenyang 110819, China
  • Received:2015-09-08 Online:2016-04-10 Published:2016-03-09
  • Contact: XU Zhangrun E-mail:xuzr@mail.neu.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.20975019, 21375012, 21305010)

摘要:

利用溴化1-丁基-3-甲基咪唑离子液体/碳酸钠溶液双水相体系, 实现了多相层流液液萃取. 以具有较高折射率的离子液体为液芯, 较低折射率的盐溶液为包层, 实现了液液波导吸光度检测. 据此建立了一种液液萃取与液液波导检测集成化的微流控分析系统. 该系统对甲酚红试样的萃取率在93%以上, 对甲酚红试样检测的线性范围为0.01~0.40 mg/mL, 相对标准偏差为3.4%(n=11), 检出限为3.8 μg/mL(3σ). 该系统将萃取分离与液液波导长光程吸光度检测集成在一起, 为拓展吸光度检测在微流控系统中的应用提供了新思路.

关键词: 微流控芯片, 离子液体双水相萃取, 液液波导, 吸光度检测, 集成化

Abstract:

A microfluidic analysis system integrated with liquid-liquid extraction and liquid-liquid waveguide detection was explored. Multiphase laminar liquid-liquid extraction was realized using 1-butyl-3-methyl imidazolium bromide ionic liquid/sodium carbonate solution aqueous two-phase system. Liquid-liquid waveguide absorption photometric detection was achieved by the ionic liquid with higher refractive index served as liquid core and the salt aqueous solution with lower refractive index served as liquid cladding. The extraction efficiency for cresol red extraction is more than 93%. The linear range, the relative standard deviation and the detection limit for cresol red detection were 0.01—0.40 mg/mL, 3.4%(n=11) and 3.8 μg/mL(3σ) respectively. Extraction separation and liquid-liquid waveguide-based long optical path absorbance detection were integrated in the system, which provided a new strategy for expanding the application of absorbance detection in microfluidic systems.

Key words: Microfluidic chip, Ionic liquid aqueous two-phase extraction, Liquid-liquid waveguide, Absorbance detection, Integration

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