Preparation of Molecularly Imprinted Monolith for Trimethoprim Molecule and Its Chromatographic Property

Chem. J. Chinese Universities

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Preparation of Molecularly Imprinted Monolith for Trimethoprim Molecule and Its Chromatographic Property

LIU Xiang-Jun, LIU Ji-Zhong, ZHAO Rui*, LIU Guo-Quan, CHEN Yi

Beijing National Laboratory for Molecular Seiences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China

Received:2007-03-05 Revised:1900-01-01 Online:2007-10-10 Published:2007-10-10
Contact: ZHAO Rui

Abstract

Abstract: A monolithic molecularly imprinted polymer(monolithic MIP) for trimethoprim(TMP) was prepared by in situ polymerization method as the HPLC stationary phase. Methacrylic acid(MAA) and ethylene glycol dimethacrylate(EDMA) were used as functional monomer and cross-linker, respectively. The obtained MIP monoliths were characterized by high performance liquid chromatography and scanning electron microscope. The SEM analysis result clearly shows that many macropores and flow-through pores were embedded in the network skeleton of the TMP-imprinted monolith, which allowed the mobile phase to flow through the monolithic MIPs with a very low flow resistance. When the flow rate was high to 9.0 mL/min, the backpressure was only 11.1 MPa. Moreover, the imprinting factor was up to 10.3, which demonstrates that the obtained monolithic MIP showed a strong affinity and selectivity to the template molecule.

Key words: Molecularly imprinted polymer, Monolith, Trimethoprim

CLC Number:

O657.32

TrendMD:

LIU Xiang-Jun, LIU Ji-Zhong, ZHAO Rui*, LIU Guo-Quan, CHEN Yi. Preparation of Molecularly Imprinted Monolith for Trimethoprim Molecule and Its Chromatographic Property[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Molecularly Imprinted Monolith for Trimethoprim Molecule and Its Chromatographic Property

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