Comparative Investigation on Acute Biological Effect of Lanthanum and Cerium by MAS 1H NMR-based Metabonomic Approach

Chem. J. Chinese Universities

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Comparative Investigation on Acute Biological Effect of Lanthanum and Cerium by MAS ¹H NMR-based Metabonomic Approach

LIAO Pei-Qiu, WU Hui-Feng, ZHANG Xiao-Yu, LI Xiao-Jing, LI Zhong-Feng, LI Wei-Sheng, WU Yi-Jie, PEI Feng-Kui

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2005-07-05 Revised:1900-01-01 Online:2006-08-10 Published:2006-08-10
Contact: PEI Feng-Kui

Abstract

Abstract: High-resolution magic-angle-spinning(MAS) ¹H NMR spectroscopic and pattern recognition(PR) based methods were applied to compare the different acute biochemical effects between La(NO₃)₃- and Ce(NO₃)₃-treated rats. Male Wistar rats were treated with various doses(2, 10, 50 mg/kg body weight) of La(NO₃)₃ and Ce(NO₃)₃, and MAS ¹H NMR spectra of the intact liver and kidney tissues were analyzed by using principal components analysis to extract metabolic information. The target lesion of La(NO₃)₃ to liver and Ce(NO₃)₃ to both liver and kidney were found by MAS ¹H NMR-PR methods. This work illustrated that the combination of NMR and pattern recognition technique is a powerful method to study the biochemical effects induced by xenobiotics.

Key words: Magic-angle spinning NMR, Metabonomics, Tissue, Rare earths, Biological effects

CLC Number:

O657.2

TrendMD:

LIAO Pei-Qiu, WU Hui-Feng, ZHANG Xiao-Yu, LI Xiao-Jing, LI Zhong-Feng, LI Wei-Sheng, WU Yi-Jie, PEI Feng-Kui. Comparative Investigation on Acute Biological Effect of Lanthanum and Cerium by MAS ¹H NMR-based Metabonomic Approach[J]. Chem. J. Chinese Universities, doi: .

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Comparative Investigation on Acute Biological Effect of Lanthanum and Cerium by MAS ¹H NMR-based Metabonomic Approach

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