Application of DNA-overoxidized Polypyrrole Composite Biosensor

Chem. J. Chinese Universities

• 研究简报 • Previous Articles Next Articles

Application of DNA-overoxidized Polypyrrole Composite Biosensor

JIANG Xiao-Hua, LIU Wei-Qiang, CHEN Jian-Jun

Center for Advanced Materials & Biotechnology, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China

Received:2006-06-26 Revised:1900-01-01 Online:2007-03-10 Published:2007-03-10
Contact: JIANG Xiao-Hua

Abstract

Abstract: A promising electrochemical microsensor was fabricated by electrochemical immobilization of DNA on a carbon fiber electrode(CFE) through an overoxidized polypyrrole(PPyox) template for simultaneous determination of serotonin(5-HT) and dopamine(DA). Such a nano-thickness DNA-PPyox biocomposite modification layer exhibited a superior selectivity and sensitivity towards these neuronal amines comparing with a simple PPyox or DNA coating. This microsensor gave three separated differential pulse voltammetric(DPV) peaks at 0.38, 0.20 and -0.02 V for 5-HT, DA and 25000-fold excess of ascorbic acid(AA). The utility of this composite biosensor was demonstrated by the determination of 5-HT content in healthy human blood serum and DA in its hydrochloric injection.

Key words: DNA-based biosensor, Overoxidized polypyrrole, Dopamine, Serotonin

CLC Number:

O657
Q523

TrendMD:

JIANG Xiao-Hua, LIU Wei-Qiang, CHEN Jian-Jun. Application of DNA-overoxidized Polypyrrole Composite Biosensor[J]. Chem. J. Chinese Universities, doi: .

[1]	YU Pengdong, GUAN Xinghua, WANG Dongdong, XIN Zhirong, SHI Qiang, YIN Jinghua. Preparation and Properties of Novel Optical and Thermal Dual Response Shape Memory Polymers [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220085.
[2]	WEI Chuangyu, CHEN Yanli, JIANG Jianzhuang. Fabrication of Electrochemical Sensor for Dopamine and Uric Acid Based on a Novel Dimeric Phthalocyanine-involved Quintuple-decker Modified Indium Tin Oxide Electrode [J]. Chem. J. Chinese Universities, 2022, 43(1): 20210582.
[3]	WANG Yupeng, ZHAO Yang, LI Mohan, SHI Suqing, GONG Yongkuan. Fabrication of Antifouling-antibacterial Dual Functional Polymer Coating via Dopamine-based Multiple Interactions [J]. Chem. J. Chinese Universities, 2021, 42(3): 811.
[4]	SUN Qirui, ZHAO Nan, LIU Shuwei, XIN Hua, ZHANG Hao, ZHANG Lening. Polydopamine-coated Fe₃O₄/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis [J]. Chem. J. Chinese Universities, 2021, 42(10): 3225.
[5]	WANG Qianying, CUI Shuxun. Investigation of Formation Mechanism of Polydopamine by Adding Free Radical Quencher ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1378.
[6]	WU Fengren,LIU Yongjia,LU Xuemin,ZHU Bangshang. Controllable Preparation of Polydopamine Modified Gold Nanoflowers and Its Application in Photothermal Therapy ^† [J]. Chem. J. Chinese Universities, 2020, 41(3): 465.
[7]	XIE Fan,WANG Yafang,ZHUO Longhai,QIN Panliang,NING Doudou,WANG Danni,LU Zhaoqing. Preparation and Properties of High Thermal Conductivity Hexagonal Boron Nitride/Aramid Fibrid Composite Film ^† [J]. Chem. J. Chinese Universities, 2020, 41(3): 582.
[8]	LIU Yun, LI Ting, WANG Yang, DONG Weifu. Preparation of Multi-scale Superhydrophobic Cotton/Polydopamine/Silica Composite for Selective Oil Absorption [J]. Chem. J. Chinese Universities, 2019, 40(8): 1775.
[9]	XIONG Zhengrong,DONG Li,LIU Xiangdong,YANG Yuming. Preparation and Properties Characterization of PDA/PVDF UV Shielding Composite Membranes [J]. Chem. J. Chinese Universities, 2019, 40(4): 849.
[10]	LI Yuan, WANG Tingting, LI Mei, CHENG Han. Determination of Dopamine Based on RO/Gold Nanoparticles-poly(dienedimethylammonium chloride) Modified Carbon Fiber Microelectrode^† [J]. Chem. J. Chinese Universities, 2018, 39(8): 1656.
[11]	YANG Shuting, LI Qianhui, FAN Yuchang, WANG Qiuxian, DU Ting, YUE Hongyun. Li₄Ti₅O₁₂ Modification by Bifunctional Bionic Membrane as Anode Materials for Lithium-ion Batteries^† [J]. Chem. J. Chinese Universities, 2018, 39(11): 2513.
[12]	CUI Guolian, DAN Nianhua, DAN Weihua. Preparation and Characterization of Novel Dopamine-based Bioadhesive Hydrogels^† [J]. Chem. J. Chinese Universities, 2017, 38(2): 318.
[13]	YU Xijuan, HAN Lulu, HUN Xu. Cu²⁺ Modified Gold Nanoclusters for Fluorescence Turn-on Detection of Dopamine^† [J]. Chem. J. Chinese Universities, 2017, 38(12): 2169.
[14]	LIU Shumin, ZHENG Yudong, LI Wei, SUN Yi, YUE Lina, ZHAO Zhenjiang. Preparation and Electrochemical Performance of 3D-nanohole PVA/a-MWCNTs Hydrogel Electrode Membrane^† [J]. Chem. J. Chinese Universities, 2016, 37(2): 290.
[15]	LIU Yuwei, GUO Zhuo. Polydopamine-doxorubicin Colloidal Nanoparticles for Chemo-Photothermal Synergistic Therapy Against Cancer Cell^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1389.

Application of DNA-overoxidized Polypyrrole Composite Biosensor

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments