Synthesis and Biological Activity of Novel Imine Derivatives Containing Triazole and Thiazole Ring

Chem. J. Chinese Universities

• 研究论文 • Previous Articles Next Articles

Synthesis and Biological Activity of Novel Imine Derivatives Containing Triazole and Thiazole Ring

SHAO Ling, ZHANG Qing, ZHOU Xin, JIN Zhong, LIU Jian-Bing, FANG Jian-Xin

State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China

Received:2006-01-15 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
Contact: FANG Jian-Xin

Abstract

Abstract: In search of low toxicity and potent fungicide, 18 novel imine derivatives containing thiazole and trizole ring were synthesized. N-Substituted benzylidene-4-(4-chlorophenyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine were synthesized from the reaction of 4-(4-chlorophenyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-yl-amine and substituted benzaldehyde. The structures of the target compounds were confirmed by elemental analysis, ¹H NMR and X-ray diffraction. The bioassay results display that some of the title compounds(6b, 6d, 6g, 6j, 6k) possess a fungicidal activity against P. piricola on test concentration(50 mg/L).

Key words: Thiazole, Triazole, Imine, Fungicidal activity

CLC Number:

O626

TrendMD:

SHAO Ling, ZHANG Qing, ZHOU Xin, JIN Zhong, LIU Jian-Bing, FANG Jian-Xin. Synthesis and Biological Activity of Novel Imine Derivatives Containing Triazole and Thiazole Ring[J]. Chem. J. Chinese Universities, doi: .

References

Related Articles 15

[1]	HUANG Qiuhong, LI Wenjun, LI Xin. Organocatalytic Enantioselective Mannich-type Addition of 5H-Oxazol-4-ones to Isatin Derived Ketimines [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220131.
[2]	TIAN Shengqiao, WEI Meiju. Reaction Mechanism for Rh（Ⅱ）-catalyzed ［3+3］ Cyclization of Indole Derivatives and Propertis of Product [J]. Chem. J. Chinese Universities, 2021, 42(6): 1899.
[3]	ZHANG Chenglu, SUN Yuedong, WANG Jing, HE Yu, ZHANG Yanpeng, ZHANG Lu, SONG Fulu. Synthesis and Application of Quinolinone Derivative Fluorescent Probe for High Selective Detection of Hg²⁺ [J]. Chem. J. Chinese Universities, 2020, 41(8): 1785.
[4]	WANG Yang, WANG Sidi, TANG Shaokun. Synthesis and Characterization of Imine-based Covalent Organic Framework(COF-LZU1) in Supercritical Carbon Dioxide [J]. Chem. J. Chinese Universities, 2020, 41(8): 1792.
[5]	GUO Zhaopei,LIN Lin,CHEN Jie,TIAN Huayu,CHEN Xuesi. Polyglutamic Acid Grafted Polyethylene Glycol@Calcium Carbonate Based Shielding System for Improving Polyethyleneimine Gene Transfection Efficiency ^† [J]. Chem. J. Chinese Universities, 2020, 41(2): 235.
[6]	DONG Xinrui, XIA Zhe, WANG Zhenxue, BIAN Qiang, LI Huabin. Design， Synthesis and Biological Activity of Pyrazole-4-carboxamides Compounds Containing 1，2，4，5-Tetrasubstituted Phenyl [J]. Chem. J. Chinese Universities, 2020, 41(12): 2759.
[7]	ZHANG Meng, WANG Shaosen, XIN Yuhao, LIU Xue, WU Qiuhua, ZHANG Guolin. Preparation and Drug Delivery Properties of Thermo/pH Dual Responsive Copolymer Composite Micelles of MPEG-b-PCL/PNVCL-b-PCL [J]. Chem. J. Chinese Universities, 2020, 41(12): 2822.
[8]	CHEN Danyi, ZHANG Fumei, HE Dan, ZHANG Zimei, ZHONG Fen, WEN Simiaomiao, LIU Qixing, ZHOU Haifeng. Synthesis of Chiral Phenylbenzothiazole Methanol via Transfer Hydrogenation Catalyzed by Ruthenium Complexes^† [J]. Chem. J. Chinese Universities, 2020, 41(10): 2264.
[9]	PAN Yixiao, LI Yanwen, HAN Jiahong, ZHAO Haoqiang, FENG Yu, DING Xiangyuan, XU Lijin, FAN Qinghua, SHI Qian. Synthesis of 1，2，3，4-Tetrahydroquinoxalines Through a One-pot Tandem Reaction Involving Cyclization and Hydrogenation of Imine and Amide Moieties [J]. Chem. J. Chinese Universities, 2020, 41(10): 2239.
[10]	XU Jianling,ZHANG Di,NIE Miaoqing,WANG Hanxi,LI Longwei. Adsorption of Cr ⁶⁺ on Polyethyleneimine-functionalized Straw Biochar from Aqueous Solution ^† [J]. Chem. J. Chinese Universities, 2020, 41(1): 155.
[11]	ZHANG Danfeng, ZHAO Maoyu, GUO Ning, TANG Songchao, ZHENG Anna. “One-pot”N-(2-Benzamidophenyl)-salicylaldehyde Imine/TiCl₄·2THF for Catalytic Ethylene Polymerization ^† [J]. Chem. J. Chinese Universities, 2019, 40(9): 2012.
[12]	XIE Xin, ZHANG Xiao, LI Ruihan, SONG Xiaoxiao, LIU Lifen, GAO Congjie. Microstructure Regulation of the Reverse Osmosis Membrane to Improve the Boron Removal Performance ^† [J]. Chem. J. Chinese Universities, 2019, 40(9): 2033.
[13]	WEI Xin, DENG Yaoliang, ZHENG Xuming, ZHAO Yanying. Ground Structure and Excited State Proton Transfer Reaction of 2-Aminobenzothiazole [J]. Chem. J. Chinese Universities, 2019, 40(8): 1679.
[14]	WANG Jinjin,QI Shaolong,DU Jianshi,YANG Qingbiao,SONG Yan,LI Yaoxian. Synthesis of Benzothiazole Fluorescent Probe for Detection of N₂H₄·H₂O and HS $O 3 - †$ [J]. Chem. J. Chinese Universities, 2019, 40(7): 1397.
[15]	DONG Lirong,WANG Siyu,ZHANG Xiaomei,CHENG Jiajia,YUAN Yaofeng. High Efficiency Catalytic Synthesis of N-Sulfonyltriazole in Aqueous Phase by Copper Sulfate/Substituted Thiourea^† [J]. Chem. J. Chinese Universities, 2019, 40(5): 927.

Synthesis and Biological Activity of Novel Imine Derivatives Containing Triazole and Thiazole Ring

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments