Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR

Chem. J. Chinese Universities

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Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR

YANG Chun-Hui¹; CHEN Jing-Wen¹; LI Qin¹; PENG Kun²; PAN Xin-Fu²; CUI Yu-Xin^1,3

1. State Key Laboratory of Natural and Biomimetic Drugs, School of
Pharmaceutical Sciences, Peking University, Beijing 100083, China;
2. Department of Chemistry, State Key Laboratory of Applied Organic
Chemistry, Lanzhou University, Lanzhou 730000, China;
3. Medical and Healthy Analysis Center, Peking University, Beijing 100083,
China

Received:2005-07-25 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
Contact: CUI Yu-Xin

Abstract

Abstract: In this paper a simpler Mosher′s method was developed from the modified Mosher′s method. It only need one configuration of MTPA to determine the absolute configurations of four αhydroxy ketones with their(S)-and(R)-MTPA esters using ¹H NMR. The signals of protons on the same side with phenyl ring will be in the higher field than those of on the different side ones.

Key words: α-Hydroxy ketones, Absolute configuration, Mosher′s method, NMR

CLC Number:

O621

TrendMD:

YANG Chun-Hui¹; CHEN Jing-Wen¹; LI Qin¹; PENG Kun²; PAN Xin-Fu²; CUI Yu-Xin^1,3. Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR[J]. Chem. J. Chinese Universities, doi: .

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Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR

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