A Covalent Organic Framework with High Surface Area for Drug Delivery †

doi:10.7503/cjcu20190087

Abstract

Abstract:

We synthesized a novel 2D covalent organic framework(COF) material with high surface area(1804 m ²/g), denoted as JUC-516, which showed ideal result in the application of drug delivery in simulated body fluid(SBF). Computational simulation by Materials Studio 7.0 software, powder X-ray diffraction(PXRD), N₂ adsorption-desorption analysis, scanning electron microscope(SEM) and Fourier transform infrared(FTIR) spectrascopy were carried out to prove the structure and property of JUC-516. JUC-516 was confirmed to be a covalent organic framework with hcb topology based on AA stack, high crystallinity and spherical morphology.

Key words: Covalent organic framework(COF), Porous material, Drug delivery

CLC Number:

O614
O622

TrendMD:

LIU Xiaozhou, WANG Yujie, LIU Yaozu, LI Zonglong, LI Hui, FANG Qianrong, JIN Yongri. A Covalent Organic Framework with High Surface Area for Drug Delivery ^†[J]. Chem. J. Chinese Universities, 2019, 40(9): 1813.

Figures/Tables 4

Fig.1 Simulated AA stacked structure(A), AB staggered structure(B) of JUC-516, PXRD patterns of JUC-516(C) and FTIR spectra of tri(4-formyldiphenyl)amine(a), 2,4,6-tri(4-amino)-1,3,5-triazine(b) and JUC-516(c)(D)

Fig.2 N2 adsorption-desorption isotherms at 77 K(A), pore size distribution derived from DFT calculation(B), TGA curve(C) and SEM image(D) of JUC-516

Fig.3 UV spectra of ibuprofen(IBU) in simulated body fluid(SBF)(pH=7.4, buffer solution) at different time(A), release profiles of IBU-loaded JUC-516(B) and illustration of ibuprofen capsulated in JUC-516 for releasing(C)

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