Construct of Nano Micelles Based on Miktoarm Star Copolymer with a Cyclodextrin Core and Their Inclusion Properties

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (8): 1896.

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Construct of Nano Micelles Based on Miktoarm Star Copolymer with a Cyclodextrin Core and Their Inclusion Properties

MU Cheng-Guang, FAN Xiao-Dong*, TIAN Wei*, BAI Yang, NAN Jiang-Kun, MA Tuo-Mei, YANG Guang

Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an 710129, China

Received:2010-09-13 Revised:2010-11-13 Online:2011-08-10 Published:2011-07-19
Contact: FAN Xiao-Dong;TIAN Wei E-mail:xfand@126.com;happytw_3000@163.com
Supported by:
国家自然科学基金(批准号: 21004049)、陕西省自然科学基础研究计划项目(批准号: 2010JQ2002)和西北工业大学基础研究基金(批准号: JC200920)资助.

Abstract

Abstract: A star-shaped polymer, MPEG-CD-PNIPAMx, which possesses the lower critical solution temperature (LCST), was designed and synthesised. MPEG-CD-PNIPAMx was composed of a β-cyclodextrin(β-CD) moiety as the core，one Methoxypolyethylene glycol (MPEG) chain and 2~4 poly(N-isopropylacrylamide)(PNIPAM) chains as double hydrophilic arms. The structure of MPEG-CD-PNIPAMx was characterized by 1H NMR, 13C NMR and the molecular weight and molecular weight distribution were measured by size exclusion chromatography/multi-angle laser light scattering(SEC/MALLS) technology. The number of PNIPAM arm was determined by integrating the peaks of 1H NMR spectrum. When the temperature of aqueous solution of MPEG-CD-PNIPAMx raises over the LCST, the star shaped molecule becomes amphiphilic, and then self-assemble into micelles with PNIPAM as the core layer, β-CD and MPEG as the shell layer. The fluorescence spectroscopy of MPEG-CD-PNIPAMx and its micelles in pyrene aqueous solution revealed that the micells can include hydrophobic guest molecule at two sites: the cavity of β-CD and the hydrophobic core of the micelle.

Key words: Cyclodextrin, Polyethylene glycol, Miktoarm star copolymer, Nano micell, Inclusion property

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MU Cheng-Guang, FAN Xiao-Dong*, TIAN Wei*, BAI Yang, NAN Jiang-Kun, MA Tuo-Mei, YANG Guang. Construct of Nano Micelles Based on Miktoarm Star Copolymer with a Cyclodextrin Core and Their Inclusion Properties[J]. Chem. J. Chinese Universities, 2011, 32(8): 1896.

References

[1] JIANG Ming(江明), Eisenberg A.(A.艾森伯格), LIU Guo-Jun(刘国军), et al.. Macromolecular Self-Assembly(大分子自组装) [M], Beijing: Science Press(北京: 科学出版社), 2006 [2] Kwon G. S. , Kataoka K.. Adv.Drug Deliv. Rev. [J], 1995, 16: 295-309 [3] Gou P. F., Zhu W. P., Xu N., et al.. J. Polym. Sci., Part A: Polym. Chem. [J], 2008, 46: 6455-6465 [4] Xu J., Ge Z. S., Zhu Z. Y., et al. . Macromolecules [J], 2006, 39: 8178-8185 [5] Cai Y. L., Tang Y. Q., Armes S. P. . Macromolecules [J], 2004, 37 (26): 9728-9737 [6] Zeng J. G., Shi K. Y., Zhang Y. Y., et al.. Chem. Commun. [J], 2008, 3753–3755 [7] Zou J., Guan B., Liao X. J., et al.. Macromolecules [J], 2009, 42: 7465-7473 [8] Liu H., Zhang Y. F., Hu J. M., et al.. Macromol. Chem. Phys. [J], 2009, 210: 2125–2137 [9] Giacomelli C., Schmidt V., Putaux J., et al.. Biomacromolecules [J], 2009, 10: 449-453 [10] Kakuchi T, Narumi A, Matsuda T, et al.. Macromolecules [J], 2003, 36: 3914-3920 [11] Dai S., Ravi P., Tan C. H., et al.. Langmuir [J], 2004, 20: 8569-8575 [12] Ravi P., Dai S., Tan C. H., et al.. Macromolecules [J], 2005, 38: 933-939 [13] Teoh S. K., Ravi P., Dai S., et al.. J. Phys. Chem. B [J], 2005, 109: 4431-4438 [14] Wang J., Jiang M.. J. Am. Chem. Soc. [J], 2006, 128: 3703-3708 [15] Liu Y. Y., Fan X. D.,Gao L.. Macromol. Biosci. [J], 2003, 3: 715-719 [16] Ciampolini M., Nardi N.. Inorg. Chem. [J],1966, 5: 41–44 [17] ZHANG Guo-Lin(张国林), WU Qiu-Hua(吴秋华), PAN Tong(潘彤), et al.. Acta Polymerica Sinica(高分子学报) [J], 2004, 2: 223-227 [18] Zhang Z. X., Liu X., Xu F. J., et al.. Macromolecules [J], 2008, 41: 5967- 5970 [19] Schild H. G.. Prog. Polym. Sci. [J],1992, 17: 163–249 [20] Kalyanasundaram K., Thomas J. K.. J. Am. Chem. Soc. [J], 1977, 99: 2039-2044 [21] Wintgens V., Charles M., Allouache F., et al.. Macromol. Chem. Phys. [J], 2005, 206: 1853-1861 [22] Hollas M., Chung M., Adams J.. J. Phys. Chem. B [J], 1998, 102: 2947-2953

Construct of Nano Micelles Based on Miktoarm Star Copolymer with a Cyclodextrin Core and Their Inclusion Properties

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