Self-assembly and Properties of Multi-sensitive Amphiphilic P(DM-co-AA-co-CA) Copolymer

Abstract

Abstract: Coumarin-containing acrylic acid monomer(CA) was designed and synthesized，which could be used together with dimethylaminoethyl methacrylate(DM) and acrylic acid(AA) to synthesize the multi-sensitive amphiphilic copolymer P(DM-co-AA-co-CA) via free radical copolymerization. Its structure was characterized by Fourier transform Infrared Spectroscopic (FTIR)、Magnetic Resonance Spectrometer (1H-NMR), Gel Permeation Chromatography (GPC) and Differential Scanning Calorimeter (DSC). The copolymer could self-assemble into steady spherical micelles in the selective solvent THF/water with suitable initial copolymer concentration and water content. The self-assembly process and characteristic of P(DM-co-AA-co-CA) micelles were studied by UV spectrophotometer、fluorescence spectrophotometer、Zeta Potential、Dynamic laser light Scattering(DLS) and Transmission Electron Microscope(TEM). The results show that in the range of pH=2.13-8.54, the UV absorbance and fluorescence emission intensity of micellar solutions increased with increasing of pH, and in the range of 8.54-12.46, both of them decreased with increasing of pH value. Depending on the solution pH, these micelles can exist in two different micellar charge states and also exhibits an isoelectric point at around pH 9.70, around which the diameter of micelle particles became the smallest, and then it increased either with the pH increasing or decreasing. In basic solution, LCST of micelles decreased with increasing of pH value, and such amphiphilic micelles are of efficient emulsification properties in pH 1.16 and 12.62.

Key words: Amphiphilic copolymer, Self-assembly, Multi-sensitive, Micelle

CLC Number:

O648

TrendMD:

GU Xin-Yan, YI Cheng-Lin, LU Yang-Bin, FAN Cun-Hua, JIANG Jin-Qiang*, LIU Xiao-Ya*. Self-assembly and Properties of Multi-sensitive Amphiphilic P(DM-co-AA-co-CA) Copolymer[J]. Chem. J. Chinese Universities, 2011, 32(8): 1889.

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