Adsorption of Bovine Serum Albumin on the Surface of Medical Polyurethane Elastomer

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (11): 2691.

• Articles • Previous Articles Next Articles

Adsorption of Bovine Serum Albumin on the Surface of Medical Polyurethane Elastomer

YIN Hong-Gen¹, HOU Feng-Wen¹, LI Yi^1*, CHENG Rong-Shi²

1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China;
2. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Received:2010-11-11 Revised:2011-05-05 Online:2011-11-10 Published:2011-10-14
Contact: LI Yi E-mail:liyi@suda.edu.cn
Supported by:
江苏省高校自然科学基础研究计划(批准号: 08KJB430014)和国家自然科学基金(批准号: 21074086)资助.

Abstract

Abstract: A special isophorone diisocyanate(IPDI) type polyurethane(PU) elastomer with good mechanical property was prepared. Heparin was grafted on the surface of this PU elastomer and a PU-Hep elastomer was obtained. The dynamic adsorption of bovine serum albumin(BSA) on PU elastomers was investigated by immersing the PU and PU-Hep elastomers in dilute BSA aqueous solution and measuring the viscosity change of the solution. The results show that BSA macromolecules quickly accumulate on the surface of PU and PU-Hep elastomers, however, it needs a long time to reach the adsorption equilibrium. The conformational chang of BSA macromolecules happens in bulk solution after adsorption on the PU and PU\|Hep elastomers.

Key words: Polyurethane elastomer; , Bovine serum albumin(BSA); , Adsorption, Viscosity

TrendMD:

YIN Hong-Gen, HOU Feng-Wen, LI Yi*, CHENG Rong-Shi. Adsorption of Bovine Serum Albumin on the Surface of Medical Polyurethane Elastomer[J]. Chem. J. Chinese Universities, 2011, 32(11): 2691.

References

参考文献 [1] Bernacca G M, Gulbransen M J, Wilkinson R, et al. In vitro blood compatibility of surface-modified polyurethanes. Biomaterials[J], 1998,19: l151-1165 [2] Blomberg E, Claesson P M. Surface coated with protein layers: a surface force and ESCA study. Biomaterials[J], 1998, 19: 371-386． [3] Khan I, Smith N, Jones E, et a1．Analysis and evaluation of a biomedical polycarbonate urathane tested in an in vitro study and an ovine arthroplasty mode1．Part I：materials selection and evaluation．Biomaterials[J], 2005, 26(5): 621-631 [4] Jiang Y, Rongbing B, Ling T, et a1. Blood compatibility of polyurethane surface grafted copolymerization with sulfobetaine monomer．Co11oids Surf B Biointerfaces[J], 2004,36(1): 27-33 [5] 胡国栋．聚氨酯的血液相容性评价, 国外医学: 生物医学工程分册[J], 2002,25(6): 271-273 [6] 许乾慰,肖世英. 脂肪族聚氨酯弹性体肝素化的血液相容性研究，中国组织工程研究与临床康复[J], 2007, 11(13):2415-2419 [7] 王琴梅,潘仕蒙,郑振声. 肝素化聚氨酯表面血小板粘附研究, 北京生物医学工程[J], 1997, l6(l):44-48 [8] Wilson D F (editor)．Techniques of Biocompatibility Testing[M]．Florida: CRC Press Inc,1984 [9] Chen H, Zhang Y, Li D, et al. Protein Adsorption on Lysine-PEG immobilized PU Surfaces. 1st Asian Biomaterials Congress, December, 2007, Tsukuba, Japan [10] Cai J, Bo S, Qin W, Yan X, Cheng R. Appl Chem. [J], 2001, 18(5): 377 -380 [11] Cheng R. Effect of adsorption on the viscosity of dilute polymer solution.Chinese Journal of Polymer Science[J], 1999,17(1): 27-35 [12] Pan Y, Cheng R. A novel interpretation of concentration dependence of viscosity of dilute polymer solution. Chineses Journal of Polymer Science[J], 2000, 18(1): 57-67 [13] 朱志博, 许宏, 路新卫, 蔡玉春. 医用聚氨酯弹性体的合成及性能研究, 第一军医大学分校学报[J], 2004, 27(1): 24-25 [14] Li Y, Cheng R. A viscometric study for gelatin in dilute aqueous solution. J.Polym.Sci. Part B: Polym. Phys.[J], 2006, 44, 1804-1812 [15] Kazuhiko l, Hisuko H, Nobuo N．An tithrombotics and antiplatelet agent in vitro blood compatibility of modified polyurethanes．Biomaterials[J], 1995, 16(11):873-879． [16] Flory P J. Principle of Polymer Chemistry[M]. Cornell University:New York, 1953. [17] Uversky V N. Narizhneva N V. Ivanova T V. Biochemistry[J], 1997, 36, 13638

Adsorption of Bovine Serum Albumin on the Surface of Medical Polyurethane Elastomer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	JIANG Hongbin, DAI Wenchen, ZHANG Rao, XU Xiaochen, CHEN Jie, YANG Guang, YANG Fenglin. Research on Co₃O₄/UiO-66@α-Al₂O₃ Ceramic Membrane Separation and Catalytic Spraying Industry VOCs Waste Gas [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220025.
[2]	HAO Honglei, MENG Fanyu, LI Ruoyu, LI Yingqiu, JIA Mingjun, ZHANG Wenxiang, YUAN Xiaoling. Biomass Derived Nitrogen Doped Porous Carbon Materials as Adsorbents for Removal of Methylene Blue in Water [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220055.
[3]	WANG Hongning, HUANG Li, QING Jiang, MA Tengzhou, JIANG Wei, HUANG Weiqiu, CHEN Ruoyu. Activation of Biochar from Cattail and the VOCs Adsorption Application [J]. Chem. J. Chinese Universities, 2022, 43(4): 20210824.
[4]	MENG Xianglong, YANG Ge, GUO Hailing, LIU Chenguang, CHAI Yongming, WANG Chunzheng, GUO Yongmei. Synthesis of Nano-zeolite and Its Adsorption Performance for Hydrogen Sulfide [J]. Chem. J. Chinese Universities, 2022, 43(3): 20210687.
[5]	CHEN Xiaolu, YUAN Zhenyan, ZHONG Yingchun, REN Hao. Preparation of Triphenylamine Based PAF-106s via Mechanical Ball Milling and C2 Hydrocarbons Adsorption Property [J]. Chem. J. Chinese Universities, 2022, 43(3): 20210771.
[6]	TAN Lejian, ZHONG Xuanshu, WANG Jin, LIU Zongjian, ZHANG Aiying, YE Lin, FENG Zengguo. Low Critical Dissolution Temperature Behavior of β⁃Cyclodextrin and Its Application in the Preparation of β⁃Cyclodextrin Sheet Crystal with Ordered Nano⁃channel [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220405.
[7]	ZHENG Meiqi, MAO Fangqi, KONG Xianggui, DUAN Xue. Layered Double Hydroxides as Sorbent for Remediation of Radioactive Wastewater [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220456.
[8]	TIAN Xiaokang, ZHANG Qingsong, YANG Shulin, BAI Jie, CHEN Bingjie, PAN Jie, CHEN Li, WEI Yen. Porous Materials Inspired by Microbial Fermentation： Preparation Method and Application [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220216.
[9]	MA Jianxin, LIU Xiaodong, XU Na, LIU Guocheng, WANG Xiuli. A Multi-functional Zn（II） Coordination Polymer with Luminescence Sensing， Amperometric Sensing， and Dye Adsorption Performance [J]. Chem. J. Chinese Universities, 2022, 43(1): 20210585.
[10]	ZHANG Chi, SUN Fuxing, ZHU Guangshan. Synthesis， N₂ Adsorption and Mixed-matrix Membrane Performance of Bimetal Isostructural CAU-21 [J]. Chem. J. Chinese Universities, 2022, 43(1): 20210578.
[11]	ZHAO Baodong, LIU Yajing, PAN Yongfei, LIU Weixiao, GAO Fulei, WANG Yinglei. Synthesis and Properties of Energetic Plasticizer 2，2-Dinitropropyl Trifluoropropanoate [J]. Chem. J. Chinese Universities, 2021, 42(9): 2815.
[12]	LIU Changhui, LIANG Guojun, LI Yanlu, CHENG Xiufeng, ZHAO Xian. Density Functional Theory Study of NH₃ Adsorption on Boron Nanotubes [J]. Chem. J. Chinese Universities, 2021, 42(7): 2263.
[13]	WANG Hongning, HUANG Li, SONG Fujiao, ZHU Ting, HUANG Weiqiu, ZHONG Jing, CHEN Ruoyu. Synthesis and VOCs Adsorption Properties of Hollow Carbon Nanospheres [J]. Chem. J. Chinese Universities, 2021, 42(6): 1704.
[14]	WANG Longjie, FAN Hongchuan, QIN Yu, CAO Qiue, ZHENG Liyan. Research Progress of Metal-organic Frameworks in the Field of Chemical Separation and Analysis [J]. Chem. J. Chinese Universities, 2021, 42(4): 1167.
[15]	JIANG Lei, YAN Shengdi, LIN Yu, WU Guozhang. Studies on Viscosity and Chemical Structure Changes in Polycarbonate Melts under Nitrogen Protection [J]. Chem. J. Chinese Universities, 2021, 42(3): 884.